Dynamics of blood coagulation system indicators depending on the severity of chronic respiratory failure and endothelial dysfunction in patients with chronic obstructive pulmonary disease

2023 Том 7, №1

D.V. Lapitski, V.A. Pupkevich, T.V. Chirikova, I.S. Dvorakovski, A.V. Goncharik, L.V. Kartun, E.V. Hodosovskaya, Zh.A. Ibrahimova, N.P. Mitkovskaya

T he publication is devoted to the study of hemostasis system parameters, markers of endothelial function, pro- and anti-inflammatory cytokines in patients with chronic obstructive pulmonary disease depending on the severity of chronic respiratory failure and disorders of arterial blood hemoglobin oxygen saturation. The authors have singled out a group of patients with signs of disseminated intravascular coagulation as a manifestation of immune thrombosis; the relationship of hemostasis disorders with hypoxemia and severe respiratory failure has been established. The authors also singled out a group of patients with the signs of thromboinflammation and demonstrated its role in vascular damage. The algorithm of clinical evaluation of patients with disseminated intravascular coagulation, and thromboinflammation is developed and their further management strategy has been suggested.

keywords: chronic obstructive pulmonary disease; chronic respiratory failure, disorders of hemoglobin oxygenation in arterial blood, disseminated intravascular coagulation, thromboinflammation.

for references: D.V. Lapitski, V.A. Pupkevich, T.V. Chirikova, I.S. Dvorakovski, A.V. Gonchari, L.V. Kartun, E.V. Hodosovskaya, Zh.A. Ibrahimova, N.P. Mitkovskaya. Dynamics of blood coagulation system indicators depending on the severity of chronic respiratory failure and endothelial dysfunction in patients with chronic obstructive pulmonary disease. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2023, vol. 7, no.1, pp. 1800–1815.

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