O.V. Laskina, G.A. Zalesskaya, N.V. Mashchar
Aim. To study metabolic processes in the blood of patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), followed by the identification of mechanisms for converting ultraviolet blood modifications (UVBM) into biological reactions.
Methods. In the course of the study, 90 blood samples were taken from patients with NSTE-ACS, whose complex treatment included UVBM with blood collection from the ulnar vein and exposure to mercury lamp radiation (“Nadezhda” device). The course of treatment consisted of 5 procedures performed once a day. The parameters of spectrophotometry, biochemical blood analysis data (electrolyte levels, Ca2+ ions, glucose, blood lipid spectrum) were studied before UVBM, directly during individual procedures and 20–30 minutes after the end of the course.
Results. Changes in the blood oxygenation parameters and the content of metabolic products were analyzed at different stages of UVBM light exposure in NSTE-ACS patients. It was revealed that the absorption of ultraviolet radiation by blood leads to its photomodification, manifested in changes in the partial pressure of blood gases. UVBM affects oxygen metabolism, changes the delivery and consumption of oxygen by tissues, and affects the course of metabolic processes. UVBM refers to physiotherapeutic methods that, when properly dosed, initiate positive changes in the balance between the production of reactive oxygen species acting as physiologically active compounds and their inhibition by antioxidant systems.
Conclusion. The systemic effect of UVBM on the body is manifested in interrelated changes in oxygenation parameters and various metabolic characteristics already during the first and then each of the subsequent procedures. The most pronounced positive changes in the oxygenation parameters and the content of metabolic products were observed during the procedures. At the end of the courses, the effect of UVBM was manifested depending on the concentration of metabolic products compared to the baseline concentration and photoinduced changes in the degree of hemoglobin oxygen saturation. Under the influence of UVBM the concentration decreased at elevated baseline values and increased at reduced. The presence of an interconnection between glucose, cholesterol and the degree of saturation of erythrocyte hemoglobin with oxygen confirms the decisive role
keywords: non-ST-elevation acute coronary syndrome, ultraviolet blood modification, metabolic processes.
for references: O.V. Laskina, G.A. Zalesskaya, N.V. Mashchar. Ultraviolet blood photomodification in patients with non-ST elevation acute coronary syndrome (Part 2). Impact on metabolic processes. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2023, vol. 7, no. 1, pp. 1816–1820.
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