A. Dalgatova, D. Torshkhoeva, E. Abdulgalimova, M. Abdulgamidov, T. Aminov, A. Isaeva
The article discusses the relationship between depressive disorders and ischemia, as well as changes in the blood coagulation system in patients with depressive disorders. Significant defects in the physiological characteristics of platelets are revealed, including increased reactivity and increased production of platelet factor 4 and p-thromboglobulin. The features of increased vasoconstriction, platelet activation, and thrombus formation are also considered, which may be the basis for the progression of coronary artery disease and mortality after acute myocardial infarction in patients with depression.
Aim. To reveal the impact of anxiety-depressive disorders on the development of cardiac muscle necrosis.
Materials and methods. Experimental and clinical studies have been carried out on patients with necrosis of the heart muscle.
Results. Patients with necrosis of the heart muscle and depression do not immediately seek medical help, unlike patients without depression. This may affect treatment options (e.g., thrombolysis) and the prognosis in such patients.
Conclusion. Further research is needed to determine whether depression causes inflammation, inflammation causes depression, or if a third, as-yet-unknown pathological process causes both inflammation and depression.
keywords: cardiac muscle necrosis, depression, anxiety, myocardium, acute heart attack.
for references: A. Dalgatova, D. Torshkhoeva, E. Abdulgalimova, M. Abdulgamidov, T. Aminov, A. Isaeva. Influence of anxiety-depressive disorders on the development of myocardial infarction. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2023, vol. 7, no. 1, pp. 1876–1800.
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