Adult-onset Still’s disease in pregnancy complicated by macrophage activation syndrome

N.I. Artishevskaia, T.G. Rayeuneva, S.E. Aliakseitshik, E.A. Mikhnevich, A.M. Malyuta

Adult-onset Still’s disease is a rare polygenicautoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain (arthritis), and a distinctive salmon-colored bumpy rash. In the past decade, some pathophysiological mechanisms of the disease have been clarified and some sensitive and specific diagnostic criteria have been suggested. The disease is considered a diagnosis of exclusion. The course of the disease can be either relatively favorable or severe and disabling. Treatment is based on the use of glucocorticoids, immunosuppressive therapy and monoclonal antibodies. In the early 21 st century, descriptions of isolated cases and small series of adult-onset Still’s disease in pregnancy appeared in literature.

keywords: adult-onset Still’s disease, pregnancy, macrophage activation syndrome

for references: N.I. Artishevskaia, T.G. Rayeuneva, S.E. Aliakseitshik, E.A. Mikhnevich, A.M. Malyuta. Adult-onset Still’s disease in pregnancy complicated by macrophage activation syndrome. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2020, vol. 4, no. 1, pp. 877–881

1. Still G.F. On a form of chronic joint disease in children. Med Chir Trans, 1897, vol. 80, pp. 47-60.
2. Bywaters E.G. Still’s disease in the adult. Ann Rheum Dis, 1971, vol. 30, no. 2, pp. 121-33. doi: 10.1136/ard.30.2.121.
3. Evensen K.J., Nossent H.C. Epidemiology and outcome of adult-onset Still’s disease in Northern Norway. Scand J Rheumatol, 2006, vol. 35, no. 1, pp. 48-51. doi: 10.1080/03009740510026616.
4. Magadur-Joly G., Billaud E., Barrier J.H., Pennec Y.L., Masson C., Renou P., Prost A. Epidemiology of adult Still’s disease: estimate of the incidence by a retrospective study in west France. Ann Rheum Dis, 1995, vol. 54, no. 7, pp. 587-590. doi: 10.1136/ard.54.7.587.
5. Kastner D.L., Aksentijevich I., Goldbach-Mansky R. Autoinflammatory disease reloaded: a clinical perspective. Cell, 2010, vol. 140, no. 6, pp. 784-790. doi: 10.1016/j.cell.2010.03.002.
6. Soroka N.F. SindromStilla u vzroslych – vzglyadna problem [Adults Still’s syndrome: outlook at problem]. Zdravoochranenie, 2014, no. 9, pp. 51-56. (in Russian).
7. Imametdinova G.R., Chichasova N.V. Bolezn’ Stillavzroslych: klinicheskiesluchai [Adult-onset Still’s disease: Clinical cases]. Sovremennayarevmatologiya, 2014, vol. 8, no. 4, pp. 39-42. (in Russian).
8. Kadavath S., Efthimiou P. Adult-onset Still’s disease-pathogenesis, clinical manifestations, and new treatment options. Ann Med, 2015, vol. 47, no. 1,pp. 6–14.
9. Kikuchi N., Satoh M., Ohtsuka M., Yamamoto T. Persistent pruritic papules and plaques associated with adult-onset Still’s disease: report of six cases. J Dermatol, 2014, vol. 41, no. 5, pp. 407-410. doi: 10.1111/1346-8138.12426.
10. Brance M.L., Neffen E.L. Oral mucosa lesions as atypical manifestation of adultonset Still’s disease. An Bras Dermatol, 2018, vol. 93, no. 2, pp. 271-273.
11. Ruscitti P., Cipriani P., Masedu F., Iacono D., Ciccia F., Liakouli V., Guggino G., Carubbi F., Berardicurti O., Di Benedetto P., Valenti M., Triolo G., Valentini G., Giacomelli R. Adultonset Still’s disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three center. BMC Med, 2016, vol. 14, no. 1, pp. 194.
12. Pouchot J., Sampalis J.S., Beaudet F., Carette S., Décary F., Salusinsky-Sternbach M., Hill R.O., Gutkowski A., Harth M., Myhal D. et al. Adult Still’s disease: manifestations, disease course and outcome in 62 patients. Medicine (Baltimore), 1991, vol. 70, no. 2, pp. 118-136. doi: 10.1097/00005792199103000-00004.
13. Yamaguchi M., Ohta A., Tsunematsu T., Kasukawa R., Mizushima Y., Kashiwagi H., Kashiwazaki S., Tanimoto K., Matsumoto Y., Ota T., et al. Preliminary criteria for classification of adult Still’s disease. J Rheumatol, 1992, vol. 19, no. 3, pp. 424-430.
14. Gerfaud-Valentin M., Hot A., Huissoud C. Durieu I., Broussolle C., Seve P. Adult-onset Still’s disease and pregnancy: about ten cases and review of the literature. RheumatolInt, 2014, vol. 34, no. 6, pp. 867-871. doi: 10.1007/s00296-013-2765-5.
15. Plaçais L., Mekinian A., Bornes M., Poujol-Robert A., Bigé N., Maury E., Fain O. Adult onset Still’s disease occurring during pregnancy: Case-report and literature review. Semin Arthritis Rheum, 2018, vol. 47, no. 4, pp. 575-577. doi: 10.1016/j.semarthrit.2017.07.003.
16. Abdulkarim S., Otieno F., Ali S.K. Adult-onset Still’s disease triggered by pregnancy. Proc (BaylUniv Med Cent), 2019, vol. 32, no. 2, pp. 229-230.
17. Ravelli A., Minoia F., Davì S., Horne A., Bovis F., Pistorio A., Aricò M., Avcin T., Behrens E.M., De Benedetti F., Filipovic L., Grom A.A. et al. 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. Ann Rheum Dis, 2016, vol. 75, no. 3, pp. 481-489.
18. Weiss E.S., Girard-Guyonvarc’h C., Holzinger D., de Jesus A.A., Tariq Z., Picarsic J., Schiffrin E.J., Foell D., Grom A.A., Ammann S.0, Ehl S., Hoshino T., Goldbach-Mansky R., Gabay C., Canna S.W. Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. Blood, 2018, vol. 131, no. 13, pp. 1442-1455.
19. Ruscitti P., Cipriani P., Masedu F., Iacono D., Ciccia F., Liakouli V., Guggino G., Carubbi F., Berardicurti O., Di Benedetto P., Valenti M., Triolo G., Valentini G., Giacomelli R. Adultonset Still’s disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three center. BMC Med, 2016, vol. 14, no. 1, pp. 194.
20. Yasin S., Schulert G.S. Systemic juvenile idiopathic arthritis and macrophage activation syndrome: update on pathogenesis and treatment. CurrOpinRheumatol, 2018, vol. 30, no. 5, pp. 514-520.

View full article

Download this article

File extension: pdf (266.59 KB)

→ Главная → 2020 Том 4, №1