F.N. Karpenko, A.V. Novik, E.D. Rasyuk, V.V. Pasyukov, V.N. Bordakov, T.V. Vaganova, O.V. Karpenko
The article presents an analysis of the modern approach to the treatment of acute obstetric hemorrhage. Some features of the preparation of leukodepleted and pathogen-reduced blood components are shown and indications for use in severe obstetric blood loss are determined. It has been shown that the pathogen reduction of blood components leads to a decrease the level of coagulation factors (coagulation factor VIII, fibrinogen in fresh frozen plasma) by 20–30 %, the activity and number of platelets by 15–20 % in platelet concentrate, does not affect the morphological usefulness of platelets. A “package” of blood components for the provision of emergency transfusion therapy for obstetric bleeding has been calculated. The need for a given quantity of blood components was determined – 2.3 “packages” per 1000 births. The proposed “emergency obstetric care packages” and the organization of their centralized delivery to medical healthcare organizations ensure a high degree of readiness of the blood service to comply with the “golden hour” rule for treating acute severe obstetric hemorrhage and minimize post-transfusion reactions and complications when using them. Pathogen-reduced blood components are expensive. Therefore, their use in clinical practice is indicated for the decreed contingents of recipients: for organ and tissue transplantation, in neonatology, oncohematology and for recipients with “multiple transfusions of blood, its components”, in cardiac surgery and obstetric practice.
keywords: acute obstetric heavy blood loss, leukodepleted and pathogen-reduced blood components

for references: F.N. Karpenko, A.V. Novik, E.D. Rasyuk, V.V. Pasyukov, V.N. Bordakov, T.V. Vaganova, O.V. Karpenko. Medical prevention of post-transfusion complications after transfusion therapy applied in case of severe obstetric blood loss. Neotlozhnaya kardiologiya i kardioovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2020, vol. 4, no. 2, pp. 1048–1056

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