I. Loginova, A. Ustinovich, E. Alferovich, I. Payuk, V. Shnitko
The problem of coronavirus infection has been the world’s concern since 2019. At the same time, the issues of infection of newborn children remain unclear, the issue of vertical transmission of the virus from mother to child is being discussed. The aim of our study was to study the features of the period of postnatal adaptation of newborns born to mothers with coronavirus infection SARS-CoV-2 (COVID-19), taking into account the time of infection occurrence. We analyzed the features of the neonatal course in children from the mothers with confirmed Covid-19 infection (PCR RNA of SARS-Cov 2) revealed in the mothers either during pregnancy or in the postpartum period. When examining children, we used clinical, laboratory, and biochemical research methods. It was found that children whose mothers contracted coronavirus infection COVID-19 immediately before childbirth had an aggravated course of the neonatal period compared with children from mothers who had recovered in the middle of pregnancy, and the manifestations of infection and post-hypoxic syndrome were more pronounced in the former. Laboratory investigations proved that newborns from the mothers who fell ill shortly before childbirth had acute viral inflammation.
keywords: coronavirus infection SARS-CoV-2 (COVID-19), newborns, ferritin, lactate dehydrogenase, cerebral depression

for references: I. Loginova, A. Ustinovich, E. Alferovich, I. Payuk, V. Shnitko. Some aspects of clinical and laboratory parameters in newborns from mothers with coronavirus infection SARS-CoV-2 (COVID-19), infected at different times of perinatal period. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2021, vol. 5, no. 1, pp. 1202–1209.

1. Namazova-Baranova L.S. Koronavirusnaya infekziya (Covid-19) u detey (sostoyanie na aprel 2020) [Coronaviral infection (COVID-19) in children (situation on April 2020)]. Pediatricheskaya farmakologiya, 2020, vol. 17, no. 2, pp. 85-94. (in Russian).
2. Molloy E.J., Bearer C.F. COVID-19 inchildrenandalteredinflammatoryresponses. Pediatr Res, 2020, vol. 88, no. 3, pp. 340-341. doi: 10.1038/s41390-0200881-y.
3. Cristiani L., Mancino E., Matera L., Nenna R., Pierangeli A., Scagnolari C., Midulla F. Will children reveal their secret? The coronavirus dilemma. Eur Respir J, 2020, vol. 55, no. 4, pp. 2000749. doi: 10.1183/13993003.00749-2020.
4. Zeng H., Хu С., Fan J., Tang Y., Deng Q., Zhang W., Long X. Antibodies in infantsвorn to mothers with COVID-19 pneumonia. JAMA, 2020, vol. 323, no. 18, pp. 1848-1849. doi: 10.1001/jama.2020.4861.
5. Dong L., Tian J., He S., Zhu C., Wang J., Liu C., Yang J. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA, 2020, vol. 323, no. 18, pp. 1846-1848. doi: 10.1001/jama.2020.4621.
6. Wang W., Xu Y., Gao R., Lu R., Han K., Wu G., Tan W. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA, 2020, vol. 323, no. 18, pp. 1843-1844. doi: 10.1001/jama.2020.3786.
7. Chen H., Guo J., Wang C., Luo F., Yu X., Zhang W., Li J., Zhao D., Xu D., Gong Q., Liao J., Yang H., Hou W., Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet, 2020, vol. 395, no. 10226, pp. 809-815. doi: 10.1016/ S0140-6736(20)30360-3.
8. World Health Organization. Coronavirus disease (COVID-2019) situation reports [electronic resource]. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.
9. Zeng L., Xia S., Yuan W., Yan K., Xiao F., Shao J., Zhou W. Neonatal early-onset infection with SARS-CoV-2 in 33 neonatesвоrn to mothers with COVID-19 in Wuhan, China. JAMA Pediatr, 2020, vol. 174, no. 7, pp. 722-725. doi: 10.1001/ jamapediatrics.2020.0878.
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