The causative agents of viral myocarditis
T.V. Amvrosieva, N.P. Mitkovskaya, Z.F. Bohush, A.S. Arinovich, E.M. Balysh
The article describes the algorithm of virological examination of patients with clinically suspected viral myocarditis and presents the results of its use in a group of 49 patients with respect to 12 causative agents of viral infections - cytomegalovirus, Epstein-Barr virus, varicella-zoster virus, human herpes virus type 6, herpes viruses types 1 and 2, enteroviruses, parvovirus B 19, hepatitis C virus, influenza A and B viruses, rhinoviruses and adenoviruses. The presence of serological markers of viral infections (antiviral IgM) was detected in 42.1% of patients, the genetic material of pathogens (RNA / DNA) in the blood serum in 16.0% of patients, in heart tissues – in 75.0%. Among the viral pathogens revealed in the biological material, adenoviruses, parvovirus B 19, and human herpes virus type 6 dominated. According to serodiagnosis IgM to enteroviruses was most often detected in blood serum.
2020 Том 4, №1
Comorbid status of patients with chronic obstructive pulmonary disease
N.Yu. Grigoryeva, M.E. Korolyova, E.M. Yashina
Aim: to study the frequency of occurrence of comorbid pathology in hospitalized patients with chronic obstructive pulmonary disease (COPD). Material and methods. We conducted a retrospective analysis of 688 “inpatient medical records” of patients undergoing treatment from September 2016 to February 2017 in City Hospital No.5 of Nizhny Novgorod, of which 142 (20.6%) patients were diagnosed with COPD. As the main disease, COPD was found in 79.6% of cases, and as a concomitant disease in 20.4% of cases. Of 142 cases, the majority of patients were men – 58.5% (83 patients), whose mean age was 67.8±12.4 years and who had a long history of smoking. 41.5% (59 patients) were women, whose mean age was 73.9±11.8 years.
2020 Том 4, №1
Pain syndrome in the postoperative period after elimination of oropharyngeal obstruction in patients with obstructive sleep apnea syndrome
Ya.E. Yaromenka, V.A. Кarnialiuk, L.E. Makaryna-Kibak, K.S. Tsishkevich
One of the components characterizing the course of the postoperative period is pain. The article analyzes the severity of pain in the postoperative period in patients with uncomplicated snoring and obstructive sleep apnea of varying severity after the surgical treatment of upper respiratory tract obstruction at the oropharyngeal level. Significant differences were found in the severity of pain in patients with uncomplicated snoring and severe obstructive sleep apnea on the 3rd, 7th, 10th and 14th days of the postoperative period. It was found that in patients with obstructive sleep apnea of moderate to severe degree, the severity of pain and dysphagia in the postoperative period and the duration of pain medication use is the greatest (p < 0.05).
2020 Том 4, №1
Differential diagnosis of arterial hypertension syndrome in young men
A.N. Zayats, V.I. Shyshko
Aim: Development of a model for the early diagnosis of arterial hypertension (AH) in men aged 18-29 years based on risk factors and structural and functional parameters of the circulatory system.
2020 Том 4, №1
Prediction of the development of renal dysfunction in patients with chronic heart failure
U.K. Kamilova, Z.D. Rasulova, N.A. Nuritdinov, D.R. Tagaeva
Aim. To identify prognostic factors for the development of renal dysfunction (RD) and to develop a method for assessing and predicting RD in patients with chronic heart failure (CHF). Methods. Totally, 101 patients with I-III functional class (FC) CHF were examined (according to the classification of the New York Heart Association). Additionally, the patients were distributed depending on the glomerular filtration rate determined by the calculation method according to the formula CKD-EPI (eGFR) into two groups: patients with eGFR ≥ 90 ml/min (n = 20), with eGFR < 90 ml/min (n = 81). In all patients there were determined: creatinine (Cr), eGFR according to the formula SKD-EPI, albumin/creatinine (Al/Cr) (mg/mmol) in morning urine, specific gravity in the morning urine (SG). We also studied renal blood flow according to Doppler ultrasonography readings at the level of the common left and right renal arteries.
2020 Том 4, №1
Effectiveness and safety of coronary arteries chronic total occlusions recanalization by retrograde approach
V.I. Stelmashok, O.L. Polonetsky, N.P. Strygo, M.G. Tsybulski, O.V. Zotova
Aim. To study effectiveness and safety of coronary arteries chronic total occlusions (CTO) recanalization by retrograde approach.
2020 Том 4, №1
Correlation of left ventricular hypertrophy with impaired filtration and tubulointerstitial kidney function in patients with hypertension
A.I. Chernyavina, N.A. Koziolova
Aim: to identify the correlation of left ventricular hypertrophy (LVH) with the development of early renal dysfunction in patients with uncomplicated HT without CKD.
2020 Том 4, №1
Clinical and epidemiological profile of outpatient venous thromboembolic complications
V.Ya. Khryshchanovich, S.S. Kalinin, I.P. Klimchuk, N.A. Rogovoy
To determine the demographic and clinical structure of venous thromboembolic (VTE) complications in the population of a large industrial center.
2020 Том 4, №1
Association of HIF-1α genetic polymorphism with the risk of obstructive sleep apnea-hypopnea syndrome in atrial fibrillation patients with ischemic heart disease and/or arterial hypertension
T.I. Balabanovich, V.I. Shishko, T.L. Stepuro, V.R. Shulika
Aim: to explore the relationship between hypoxia inducible factor-1α (HIF-1α) (С1772T) gene polymorphism and the risk of obstructive sleep apnea-hypopnea syndrome (OSAHS) in atrial fibrillation (AF) patients with ischemic heart disease and/or arterial hypertension.
2019 Том 3, №2
Wrapping of the dilated ascending aorta in patients with aortic valve pathology
D.А. Bozhko, Y.М. Chesnov, S.V. Spiridonov, S.А. Kurganovich
The method for ascending aorta wrapping developed at the “Cardiology” Republican Scientific and Practical Centre, Belarus, has been used in the treatment of 93 patients. The analysis of early and long-term treatment results was performed. A short time of ischemia and cardiopulmonary bypass, a low level of postoperative complications, including repeated operations for bleeding (3.23%) were noted. According to echocardiography data, a significant decrease in the average diameter of the ascending aorta, from 45.33 ± 3.12 mm to 36.26 ± 4.09 mm, was marked. In the long-term follow-up period no significant changes in the size of the ascending aorta at all levels were observed; rapid aorta dilatation, aneurysm formation, dissection, aorta rupture, and such complications as uterus erosion, dislocation of the wrap and aortic kinking were also not revealed.
2019 Том 3, №2
Specific features of lipid metabolism in children with cardiac risk factors
O.N. Volkova, V.D. Yushko, N.N. Bylinskiy, V.V. Strogiy
The article presents the data on the role of lipid metabolism disorders, including fatty acid metabolism disorders, among children with cardiac risk factors: arterial hypertension, obesity and aggravated atheroselrosis heredity.
2019 Том 3, №2
The role of endothelial dysfunction and oxidative stress in the formation of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease
N.Yu. Grigoryeva, M.V. Mayorova, M.O. Samoluk, T.P. Ilyushina
The purpose of this study was to evaluate oxidative stress and endothelial dysfunction in patients with chronic obstructive pulmonary disease (COPD) who had concomitant cardiovascular pathology.
2019 Том 3, №2
The level of homocysteine and polymorphisms of genes of folate exchange in patients with coronary heart disease and diabetes mellitus type 2
E.V. Davydchyk, V.A. Snezhitskiy, T.L. Stepuro, E.M. Doroshenko, V.Yu. Smirnov
The aim of the study is to investigate the level of homocysteine (Hcy), distribution of frequencies of alleles and genotypes of polymorphic options С677Т, А1298С of gene MTHFR, A66G of gene MTRR, А2756G of gene MTR in patients with chronic coronary heart disease (CHD) in combination with diabetes mellitus (DM) type 2.
2019 Том 3, №2
Adipose tissue metabolic activity in chronic obstructive pulmonary disease patients in case of chronic nonspecific inflammation
D.V. Lapitski, A.N. Ryapolov, V.A. Pupkevich, T.V. Chirikova, I.B. Butyanovskaya, R.F. Ermolkevch, A.A. Arabey, A.V. Goncharik, G.A. Ibragimova, N.P. Mitkovskaya
The article addresses the dynamics of adipose tissue hormones leptin (LN) and adiponectin (AN) depending on nonspecific inflammation (NI) degree, as well as relations between adipokin and glucose/lipids metabolic disorders, adipose tissue capacity with different NI degrees in patients with chronic obstructive pulmonary disease (COPD). NI is associated with a high AN degree and a low LN degree which promotes the increase in metabolic substrata intake for immunity caloric supply. NI decrease is associated with a low AN degree and a highLN degree which promotes increase in adipose tissue capacity and worsening of glucose/lipids metabolic disorders. Nebivolol administration is associated with increase in AN level. Statins administration results in decrease in AN level and increase in LN level, due to reduced NI. Thus, treatment strategy in COPD patients should include some measures to prevent adipose tissue capacity increase and glucose/lipids metabolic disorders when NI is reduced.
2019 Том 3, №2
Evaluation of health-related quality of life in patients with avascular necrosis
N.А. Martusevich, К.V. Gudkevich
Aim: to evaluate Health-Related Quality of Life (HRQL) in patients with avascular necrosis (AN) and to identify the most significant risk factors, which lead to low HRQL in patients with AN.
2019 Том 3, №2
Results of factor analysis of laboratory resistance markers to acetylsalicylic acid in patients with stable angina
T.P. Pronko, V.A. Snezhitskiy, V.R. Shulika
The aim of the study was to assess the markers influencing the development of acetylsalicylic acid (ASA) laboratory resistance in patients with stable angina.
2019 Том 3, №2
Non-sjögren syndrome dry eye in general medical practice: causes, outcomes, treatment tactics
G.R. Semak, V.A. Zaharava, S.K. Kletsky, T.A. Liatkovskaya, I.Yu. Zherko
Recently, non-Sjogren’s eye disease (DED) has become increasingly frequent in the therapeutic practice. In the Republic of Belarus, about 17–25% of the population over 40 years old suffer from corneal conjunctival xerosis of various severity. DED can develop both as an outcome of eye diseases and on the background of somatic pathology (diabetes mellitus, systemic atherosclerosis, menopausal syndrome, arterial hypertension, thyroid disease and metabolic syndrome) and is often associated with the systemic and topical use of medications (β-blockers, diuretics, analgesics, antidepressants, etc.). With the progression of corneal dystrophy and albugo formation, various types of donor cornea keratoplasty are used. In the best clinics, a 5-year transplant survival associated with the tear film deficiency is less than 50%.
2019 Том 3, №2
Prevention of cardiovascular complications in the long-term period of initial percutaneous coronary intervention
N.L. Tsapaeva, S.F. Zolotuhina, E.V. Mironova, N.V. Tarashkevich, N.I. Egorova
The aim of present study investigate the clinical, instrumental and biochemical markers of the risk of cardiovascular complicated in long-term of initial percutaneous coronary intervention.
2019 Том 3, №2

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