Latest Tables of Contents with Summaries

2023 Том 7, №1
Acute myocardial injury in COVID-19 patients: pathogenetic aspects and differential diagnosis considerations
A.A. Pleshko, E.B. Petrova, E.A. Grigorenko, T.V. Gorbat, S.V. Gunich, N.P. Mitkovskaya
I n the light of COVID-19 pandemic caused by SARS-CoV-2 virus, cardiovascular complications become a medical and social problem, the significance of which increases in the post-acute phase. Cardiovascular events against COVID-19 include both acute ischemic and non-ischemic myocardial injury – up to 21%, acute heart failure, rhythm and conduction disorders (up to 15%), venous (up to 7% in patients in the general department and up to 22% in the intensive care unit) and arterial thrombotic complications (up to 11%). The retrospective analysis of medical records of 10 908 inpatients aged 18 to 90 years, who were treated from June 01, 2020 to May 31, 2021 in The 4th City Clinical Hospital named after M.J. Saŭčanka was performed. Prevalence of myocardial injury developed against the background of SARS-CoV-2 was 5.28% (n = 576), it was observed in patients of different age groups, including those without previous cardiovascular history. The article presents an analysis of current worldwide data on pathogenetic aspects of acute myocardial injury in patients with COVID-19. It is noted that cardiac MRI is an effective, accurate and noninvasive method of differential diagnosis of ischemic and inflammatory myocardial injury in COVID-19. The algorithm for differential diagnostics of acute myocardial injury in this category of patients is proposed.
A multimodal approach to heart failure risk assesment in patients with acute myocardial infarction (part 2). Instrumental and imaging predictors
N. Tsapaeva, S. Zolotuhina, Е. Mironova, Е. Burakovskaja, A. Viarsotski
A cute myocardial infarction (AMI) is a starting point for the development of heart failure (HF), which increases the risk of death. The development of HF in AMI patients significantly worsens the prognosis and increases treatment costs, which determines the medical and social significance of the problem. This not only emphasizes the necessity of careful monitoring of AMI patients, but also is a reasonable motivation for the use of multimodal approach to determine the individual risk of heart failure development in patients with AMI, since different pathogenetic mechanisms with different contribution of leading disorders are involved in HF development: microcirculatory dysfunction, inflammation, hemorrhage, edema, remodeling. Multimodal approach is implemented by the identification of clinical, laboratory, angiographic and imaging predictors of HF development. For risk stratification it is necessary to substantiate the optimal combination of prognostic methods to determine the degree of heart failure development risk, the key pathogenetic mechanism of its development and, accordingly, to use the most adequate treatment regimens.
Angina without obstructive coronary artery disease (part 3). Modern treatment strategies
S. Solovey
T he main cause of angina in patients without obstructive coronary artery (CA) disease is vasomotor dysfunction, including various pathophysiological endotypes: macro- or microvascular vasospasm, reduced microvascular vasodilation or increased resistance, as well as their combinations. Such patients not only have persistent angina symptoms, leading to frequent hospitalizations and repeated diagnostic tests for obstructive coronary heart disease (CHD), but also an increased risk of adverse cardiovascular events. In such cases, standard antianginal therapy turns out to be less effective, and the development of new pharmacological agents specific for this variant of CHD still remains an unsatisfied need. At the same time, it has been shown that compliance with the treatment protocol corresponding
to a specific disease endotype improves symptom control and quality of life.
Treatment of patients includes lifestyle modification measures with control
of cardiovascular risk factors, and antianginal therapy, the targeting of which requires accurate, in most cases invasive, diagnosis of pathophysiological endotype. An important component of the treatment process is a non-drug effect, especially in patients with refractory angina pectoris. The article discusses various treatment options (including experimental) and their rationale in patients with angina pectoris without obstructive lesions of the СА.
Incidence and risk factors for low cardiac output syndrome after open heart surgery
R. Yarosh, L. Shestakova, M. Bushkevich, N. Petrovich
Purpose. To study the incidence and to determine predictors of post cardiotomy low cardiac output syndrome after open-heart surgery.
Methods. A retrospective, observational case-control study was conducted at the Republican Scientific and Practical Center of Cardiology for the period 2015–2017. The study included 1, 540 patients who underwent open-heart surgery. Intraoperatively and in early postoperative period, 46 patients developed postcardiotomy low cardiac output syndrome (PCLCOS) refractory to drug therapy, followed by mechanical circulatory support (the study group), the comparison group consisted of 1, 494 patients.
Results. The incidence of PCLCOS was 2.98%. The predictors of PCLCOS included the following: reoperation OR = 3.65 (95% CI 1.40–9.51), myocardial infarction (30 days) before operation OR = 7.20 (95% CI 2.25–23.01), heart failure NYHA class III/IV OR = 2.38 (95% CI 1.30–4.37), and preoperative local contractility index more than 1.81, OR = 2.92 (95% CI 1.50–5.68).
Conclusion. Postcardiotomy low cardiac output syndrome is still a big issue in cardiac surgery. Despite modern methods of myocardial protection and mechanical circulatory support (MCS), hospital mortality remains extremely high, up to 80%. Prognosis based on predictive models will allow timely selection of the required type of MCS, reducing the incidence of multiple organ failure, and, as a result, adverse outcomes of surgical treatment.
Effect of hibernating myocardium on postischemic left ventricular dysfunction after surgical coronary reperfusion. Part 1
N. Shybeko, L. Gelis, T. Rusak, Yu. Belinskaya
S o far, surgical interventions with artificial circulation remain the most effective treatment method providing favorable long-term outcomes, prognosis and quality of life in patients with coronary heart disease (CHD). Therefore, the main issue of cardiologists and cardiac surgeons is the prognosis of functional recovery of the left ventricle after revascularization, as the treatment strategy is determined by the risk assessment of surgical mortality and perioperative complications. In order to detect hibernating myocardium, we performed a prospective study including 57 patients with CHD and upcoming coronary bypass grafting, mitral valve plasty or prosthesis. All patients underwent stress magnetic resonance imaging, which allowed noninvasive assessment of both structural and functional changes, as well as determination of myocardial functional reserve. The obtained data will allow us to objectively assess the surgical risk during cardiac surgical interventions, which is very important for the prevention of life-threatening cardiovascular complications, as well as increasing the efficiency of surgical treatment in patients with CHD.
Mid-term and long-term outcomes of functional mitral insufficiency interventional treatment in patients with cardiomyopathy
O. Shatova, T. Denisevich, E. Kurlyanskaya, O. Poloneckij, T. Asmalouskaya
T he article presents the outcomes of treatment of patients with cardiomyopathy and pronounced functional mitral insufficiency 6, 12 and 24 months after MitraClip device implantation. We observed that 6 months after the intervention, there was regression of left heart chamber remodeling, as well as positive dynamics of right ventricular ejection fraction and pulmonary artery pressure against the background of mitral valve improvement. The achieved effect of improved intracardiac hemodynamics persisted in 12 months after mitral valve clipping. After 12 months, there were signs of left ventricular remodeling without significant changes in valve characteristics and left atrial parameters. During the first 6 to 12 months after MitraClip implantation, the distance walked in the 6-minute walk test and peak oxygen consumption increased, with retention of high values of these indicators in 24 months of follow-up.
Preclinical cardiotoxicity in systemic treatment of resectable breast cancer
S.V. Chernyak, Ye.V. Kovsh, M.V. Chernevskaya, T.V. Sevruk, T.V. Gorbat, L.V. Rachok, N.N. Akhmed, O.S. Pavlova
S tudy of cancer patients and assessment of the cardiotoxicity risk of chemotoxic drugs has been performed using the following diagnostic methods: echocardiography with assessment of global myocardial deformation, cardiac magnetic resonance imaging, analysis of cardiac biomarkers and arterial stiffness. Application of the mentioned methods allowed to detect subclinical heart and vascular lesions before the appearance of clinical symptoms in patients resectable breast cancer and systemic treatment.
Diagnosis of silent myocardial ischemia and cardiovascular risk stratification according to imaging methods in patients with different variants of adipose tissue distribution
I. Patsiayuk, N. Mitkovskaya, T. Rusak, T. Statkevich, T. Gorbat, V. Terechov, O. Semenyuk
Purpose. To identify the peculiarities of perfusion disorders, and stratify cardiovascular risk in asymptomatic patients with different variants of adipose tissue distribution.
Materials and methods. Our research included 80 patients with episodes of asymptomatic diagnostically significant ST-segment depression detected during daily electrocardiogram monitoring (daily ECG). These patients were divided into two groups. The first group consisted of 47 patients with abdominal obesity (АО+), and the second group – without АО (АО-). The first group was further divided into two subgroups depending on the volume of epicardial adipose tissue (with and without epicardial obesity): (EO+) and (EO-). Daily ECG monitoring, multispiral computed tomography (MSCT) with calculation of indicators of epicardial adipose tissue and calcium score (CS), stress single-photon emission computed tomography (stress-SPECT) of the myocardium were held. Summed stress score (SSS) was used for cardiac risk stratification.
Results. Daily ECG monitoring revealed that the total duration of ST-segment depression per day and the number of episodes were greater in the AO+ group compared to the AO- group. Perfusion defects were found in 93.75% of patients (including 95.7% in the AO+ group and 90.9% in the AO- group) during SPECT. There were no significant differences in the values and area of the perfusion defect at rest and after the stress test between the AO+ and AO- groups. In the subgroup of patients with EO+, more complex types of rhythm disturbances prevailed. The EO+ group exhibited higher values of CS, stress-SPECT showed induced deterioration of myocardial perfusion, and 21.7% of patients had an SSS score of more than 8, corresponding to a moderate risk of myocardial infarction and cardiac death.
Conclusions. SPECT of the myocardium verified perfusion defects in 93.75% of the patients included in the research. There were no significant intergroup differences in the parameters characterizing myocardial perfusion defects depending on the presence of AO. Myocardial ischemia was more pronounced among patients with EO and was accompanied by significant arrhythmias. The individuals with epicardial obesity exhibited more pronounced calcification of the coronary arteries compared to patients without epicardial obesity. The obtained data indicate that epicardial obesity is a factor that increases cardiovascular risk in patients with silent myocardial ischemia.
Ultraviolet blood photomodification in patients with non-st elevation acute coronary syndrome (part 2). Impact on metabolic processes
O.V. Laskina, G.A. Zalesskaya, N.V. Mashchar
Aim. To study metabolic processes in the blood of patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), followed by the identification of mechanisms for converting ultraviolet blood modifications (UVBM) into biological reactions.
Methods. In the course of the study, 90 blood samples were taken from patients with NSTE-ACS, whose complex treatment included UVBM with blood collection from the ulnar vein and exposure to mercury lamp radiation (“Nadezhda” device). The course of treatment consisted of 5 procedures performed once a day. The parameters of spectrophotometry, biochemical blood analysis data (electrolyte levels, Ca2+ ions, glucose, blood lipid spectrum) were studied before UVBM, directly during individual procedures and 20–30 minutes after the end of the course.
Results. Changes in the blood oxygenation parameters and the content of metabolic products were analyzed at different stages of UVBM light exposure in NSTE-ACS patients. It was revealed that the absorption of ultraviolet radiation by blood leads to its photomodification, manifested in changes in the partial pressure of blood gases. UVBM affects oxygen metabolism, changes the delivery and consumption of oxygen by tissues, and affects the course of metabolic processes. UVBM refers to physiotherapeutic methods that, when properly dosed, initiate positive changes in the balance between the production of reactive oxygen species acting as physiologically active compounds and their inhibition by antioxidant systems.
Conclusion. The systemic effect of UVBM on the body is manifested in interrelated changes in oxygenation parameters and various metabolic characteristics already during the first and then each of the subsequent procedures. The most pronounced positive changes in the oxygenation parameters and the content of metabolic products were observed during the procedures. At the end of the courses, the effect of UVBM was manifested depending on the concentration of metabolic products compared to the baseline concentration and photoinduced changes in the degree of hemoglobin oxygen saturation. Under the influence of UVBM the concentration decreased at elevated baseline values and increased at reduced. The presence of an interconnection between glucose, cholesterol and the degree of saturation of erythrocyte hemoglobin with oxygen confirms the decisive role
Dynamics of blood coagulation system indicators depending on the severity of chronic respiratory failure and endothelial dysfunction in patients with chronic obstructive pulmonary disease
D.V. Lapitski, V.A. Pupkevich, T.V. Chirikova, I.S. Dvorakovski, A.V. Goncharik, L.V. Kartun, E.V. Hodosovskaya, Zh.A. Ibrahimova, N.P. Mitkovskaya
T he publication is devoted to the study of hemostasis system parameters, markers of endothelial function, pro- and anti-inflammatory cytokines in patients with chronic obstructive pulmonary disease depending on the severity of chronic respiratory failure and disorders of arterial blood hemoglobin oxygen saturation. The authors have singled out a group of patients with signs of disseminated intravascular coagulation as a manifestation of immune thrombosis; the relationship of hemostasis disorders with hypoxemia and severe respiratory failure has been established. The authors also singled out a group of patients with the signs of thromboinflammation and demonstrated its role in vascular damage. The algorithm of clinical evaluation of patients with disseminated intravascular coagulation, and thromboinflammation is developed and their further management strategy has been suggested.
Hospital outcomes of surgical treatment for functional tricuspid valve insufficiency depending on the chosen method of surgical treatment
V.G. Krutov, V.V. Shumovets, Yu.P. Ostrovsky, I.E. Andraloits, E.R. Lysenok, I.I. Grinchuk, N.L. Uss, S.V. Koval
Purpose. To study and compare hospital outcomes of surgical treatment of functional (secondary) tricuspid insufficiency, depending on its etiology and on the chosen surgical method of its correction.
Materials and methods. We performed clinical and hemodynamic evaluation of the outcomes of various methods of cardiac surgical treatment of patients with non-rheumatic tricuspid valve (TV) insufficiency (functional) in chronic forms of coronary artery disease (CAD), and delated cardiomyopathy (DCM). The study included 792 patients who during a period from 2011 to 2020 underwent correction of non-rheumatic TV insufficiency (functional): There were 642 participants with CAD, 150 participants with DCM. We assessed their echocardiographic parameters.
Results. In the analyzed sample at the hospital stage, there was a signi ficant decrease in the severity of tricuspid insufficiency after the performed TV repair. We found no influence of the etiology of TV lesion on the incidence of residual tricuspid insufficiency grade ≥ II at the hospital stage. In general, there was no effect of the TV plasty method (annuloplasty or suture techniques) on the incidence of residual tricuspid insufficiency grade ≥ II at the hospital stage. But significant differences were found depending on the specific method of annuloplasty both in patients with CAD and in patients with DCM: the maximum incidence of residual tricuspid regurgitation (TR) grade ≥ 2 was registered after soft ring annuloplasty, the minimum was after annuloplasty with soft semi-ring made of felt strips according to the original method. At the same time, after performing annuloplasty with a soft half-ring made of felt strip according to the original method in patients with DCM, no recurrence of TR grade ≥ 2 was noted in any patient. Also, in the analyzed sample, significant differences were found depending on the type of corrector ring implanted during annuloplasty: when implanting the Plankor-A corrector ring, as well as the Medtronic Contour 3D corrector ring, the frequency of residual TR grade ≥ 2 was minimal, slightly higher with the implantation of the Plankor-T corrector ring, and maximum with the implantation of the Carperntier Edwards MC3 corrector ring.
Conclusion. The etiology of TV lesions does not affect the incidence of clinically significant residual tricuspid insufficiency. In general, the groups of ring and suture plasty methods did not differ in the incidence of residual tricuspid insufficiency grade ≥ II at the hospital stage. But among all methods of annuloplasty, the lowest frequency of clinically significant residual TR was observed after annuloplasty with a soft semi-ring made of felt strip according to the original method.
Mobile application for predicting left ventricular systolic function during breast cancer treatment with anthracyclines
N. Kananchuk, S. Kananchuk, E. Petrova, M. Abramovich, N. Kazlouskaya, N. Mitkovskaya
Purpose. To evaluate the effect of complex treatment of breast cancer (BC) on the parameters of systolic myocardial function, and the efficiency of the prescription of cardiotropic therapy (CT) – a fixed combination of valsartan and carvedilol – in the prevention of the identified changes. To develop a mobile application, namely, an electronic statistical alculator for calculating the left ventricular ejection fraction by Simpson during BC treatment with anthracyclines, using the baseline anthropometric and instrumental data of the patient.
Methods. We evaluated the cardiovascular health of 100 women who received complex treatment of BC. The patients were divided into three groups, depending on the presence of arterial hypertension and the prescription of CT. In the study, all women received a complex evaluation of the cardiovascular health at the beginning and at the end of BC treatment
Results. In the non-CT group after the end of complex BC treatment the following was found: a decrease in the shortening fraction (FS) from 41.0 (38.0; 45.0)% to 38.0 (35.0; 43.0)%, (p < 0.05), in ejection fraction (EF) by Teinholz from 72.0 (69.0; 76.0)% to 68.0 (64.0; 73.0)%, (p < 0.05); in ejection fraction by Simpson from 66.0 (62.0; 71.0)% to 60.0 (57.0; 66.0)%, (p < 0.05); an increase in the vagosympathetic interaction LF/HF index (ratio of low frequency (LF) to high-frequency (HF) components) from 0.8 (0.7; 1.0) to 1.05 (0.8; 1.2), (p < 0.05); reduction of brachial artery diameter change from 12.5 (11.0; 16.0)% to 9.0 (6.0; 12.0)%, (p < 0.05). A model of the prognosis of EF by Simpson during BC treatment was proposed, which included a total dose of doxorubicin calculated per body surface area, early diastolic rate of transtricuspid blood flow, diameter of the trunk of the pulmonary artery, the rate of circular shortening of myocardial fibers, thickness of the intima-media complex of the left carotid arteries, HF, % of brachial artery diameter change. The prognosis model formed the basis for the development of the mobile application for predicting left ventricular systolic function during BC treatment with anthracyclines. We proposed a model for prediction of LVEF by Simpson against during breast cancer treatment, which included the total doxorubicin dose calculated per body surface area, early diastolic rate of transtricuspidal blood flow, pulmonary artery trunk diameter, myocardial fiber circular shortening rate, left carotid artery intima-media complex thickness, HF, percentage of brachial artery diameter change. The prognostic model formed the basis for the development of the mobile application for predicting left ventricular systolic function during BC treatment with anthracyclines.
Long-term outcomes of minimally invasive epicardial video-assisted radio-frequency isolation of pulmonary veins and posterior wall of the left atrium “BOX LESION” in isolated atrial fibrillation using COBRA TECHNOLOGY
A.S. Zhyhalkovich, R.R. Zhmailik, V.I. Sevrukevich
Purpose. To analyze long-term outcomes of minimally invasive epicardial video-assisted radiofrequency ablation (RFA) of the pulmonary veins (PV) and the posterior wall of the left atrium “box lesion” using Cobra technology in patients with various forms of isolated atrial fibrillation (AF).
Materials and methods. From September 2011 to November 2021, 85 patients (70 male, 15 female) suffering from various forms of idiopathic AF underwent surgery on the basis of the Republican Scientific and Practical Center of Cardiology, Republic of Belarus. The patients were operated on using epicardial video-assisted RFA of the PV and posterior wall of the left atrium “box lesion” using Cobra Adhere (45 patients) and Cobra Fusion (40 patients) devices. Mean age 53.8±8.80 years (28–71). History of AF – the burden of fibrillation before the surgery was 58.6±32.50 months. 35.3% (30 patients) had previously undergone ineffective PV catheter ablation.
Results. There were no lethal cases, as well as conversions to sternotomy, acute cerebrovascular accidents during the hospital period. The follow-up perio was studied in 100.0% of patients, the average follow-up period was 7.1+2.1 years. To evaluate the results, Holter monitoring was used after 3, 6, 12 months. after surgery, then annually, the readings of event monitors and the results of pacemaker programming. Positive results included sinus rhythm (SR) without AF/Atrial paroxysms for more than 30 s, as well as atrial (AAI) or dual-chamber DDD(R) pacing. The effectiveness of RFA of the PV and the posterior wall of the left atrium “box lesion” using Cobra Adhere and Cobra Fusion devices, depending on the initial type of AF in the long-term period (3 years), was: 56.3% /70.6% for paroxysmal AF, 28.0% / 44.4% for persistent AF, 0%/0% for long-standing persistent AF.
Conclusion. The Cobra technology proved to be the most effective in paroxysmal AF, less optimal results were obtained in persistent AF. In general, more consistent results were obtained with the Fusion technology. Efficacy also depended on the length of the follow-up, with the number of patients with sustained sinus rhythm decreasing over time and requiring additional catheter procedures in symptomatic patients.
Left ventricular myocardial longitudinal strain and dyssynchrony in patients with ventricular pacing in the long-term postoperative period
A. Harypau, I. Patsiayuk
Purpose. To study the parameters of longitudinal strain of the left ventricular myocardium and dyssynchrony in young patients with ventricular pacing in the long-term postoperative period. Materials and methods. The study included 60 patients aged 18 to 35 with pacemakers. The first group consisted of 30 patients (17 men and 13 women) with permanent pacemakers implanted after surgical correction of congenital heart defect (CHD) due to postoperative atrioventricular block (AV block). The second group included 30 patients (18 men and 12 women) with non-surgical AV block who required the implantation of a permanent pacemaker. All patients underwent echocardiography to determine the longitudinal strain
of the left ventricular (LV) myocardium and assess dyssynchrony. Results. Significant differences were found in the study groups regar - ding regional and total global longitudinal strain (GLS) of the LV myocardium. In group 1, the strain in the apical dual–chamber position (AP2) was –16.1 (–17.0; –10.9)% and –18.3 (–20.1; –15.0)% in the 2nd (U = 287.0, р = 0.016); in the apical three–chamber position (AP3) –15.2 (–17.7; –11.8)% and 18.3 (–20.1; –17.2)%, respectively (U = 258,5, p = 0.004); in the apical four–chamber position (AP4) –14.8 (–17.6; –11.8)% and –17.1 (–18.4; –15.5)%, respectively (U = 189.5, p = 0.000). GLS in the study groups was –15.4 (–16.8; –12.3)%
and –17.9 (–19.0; –16.5)%, respectively (U = 193.5, p = 0.000). The share of patients with GLS over –16% in group 1 after CHD surgical correction was 57%, which is significantly higher than in the group with non–surgical AV block (23%) (χ2 = 6.94, p = 0.008). Interventricular mechanical delay did not differ significantly between the groups, with values of 40.5 (15.0; 54.5) ms and 28.5 (7.0; 53.0) ms, respectively (U = 343.5, p = 0.236). Intraventricular dyssynchrony was more pronounced in group 1 and totaled 121.0 (99.0; 140.0) ms compared to 84.0 (63.0; 106.0) ms in group 2 (U = 192.0, p = 0.000). The width of the QRS complex was significantly greater in group 1 compared to group 2, with values of 140 (140; 160) ms and 140 (130; 140) ms, respectively (U = 302.0, p = 0.028). Conclusion. We found that patients with prolonged ventricular pacing after CHD surgical correction, compared with patients with non-surgical AV block, have significantly lower values of total and regional longitudinal strain, as well as more pronounced dyssynchrony, which indicates the presence of systolic myocardial dysfunction and LV remodeling in this population and suggests an increased risk of developing pacemaker-induced cardiomyopathy (PICM).
The concept of harm reduction from non-communicable disease risk factors as the basis of the national public health policy of The Republic Of Belarus
D. Ruzanov, I. Malakhova, A. Semyonov, V. Pisarik
N on-communicable diseases have become a global challenge in recent years, and their prevalence is significantly affecting countries worldwide, including the Republic of Belarus. These diseases are influenced by various factors such as behavior, genetics, environment, and social conditions, all of which contribute to the increased likelihood of disease development, progression, and unfavorable outcomes. Risk factors associated with non-communicable diseases include smoking, alcohol abuse, and excessive consumption of salt and sugar. In Belarus, there is a high prevalence of these risk factors, leading to increased morbidity, disability, and mortality rates. Therefore, it is crucial to address the prevention and mitigation of the impact of these risk factors on the human body. A modern approach to tackling non-communicable diseases involves the prevention and control
of these risk factors.
The purpose of this study is to establish and develop the key principles of a concept for reducing harm caused by specific risk factors of non-communicable diseases, such as tobacco smoking, alcohol abuse, and excessive salt and sugar consumption. This concept will serve as the foundation for the national public health policy of the Republic of Belarus. The justification for developing a harm reduction concept stems from assessing the consequences of the high prevalence of noncommunicable diseases and their associated risk factors in Belarus. Furthermore, the study considers global theoretical frameworks, scientific debates on harm reduction, and analysis of successful practices implemented in other countries.
We have developed the key provisions of the Harm Reduction Concept and outlined its prospects for subsequent inclusion in the state program “People’s Health and Demographic Security.” Additionally, we have formulated recommendations for regulators based on regulatory differentiation.
Cellular structure of atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall
M. Kazakova
A therosclerosis is a chronic inflammatory disease of the arteries that occurs during a complex interaction between risk factors (low-density lipoprotein cholesterol, obesity, diabetes mellitus, hypertension, smoking, etc.), components of the vascular wall, as well as immune and inflammatory cells. Various cells from intima, media, adventitia and perivascular adipose tissue not only make up an intact and normal arterial vessel wall, but also participate in the inflammatory reaction in atherosclerosis.
The process of atherosclerosis is initiated by activation of the endothelium, followed by a cascade of events (accumulation of lipids, migration and proliferation of smooth muscle cells, transformation of fibroblasts into myofibroblasts). The atherosclerotic plaque causes narrowing of the vessel and leads to cardiovascular complications. The article reviews the results of recent studies that reveal the role of various cells of the arterial vessel wall, as well as cells of innate and adaptive immunity in the development of atherosclerosis.
Influence of anxiety-depressive disorders on the development of myocardial infarction
A. Dalgatova, D. Torshkhoeva, E. Abdulgalimova, M. Abdulgamidov, T. Aminov, A. Isaeva
The article discusses the relationship between depressive disorders and ischemia, as well as changes in the blood coagulation system in patients with depressive disorders. Significant defects in the physiological characteristics of platelets are revealed, including increased reactivity and increased production of platelet factor 4 and p-thromboglobulin. The features of increased vasoconstriction, platelet activation, and thrombus formation are also considered, which may be the basis for the progression of coronary artery disease and mortality after acute myocardial infarction in patients with depression.
Aim. To reveal the impact of anxiety-depressive disorders on the development of cardiac muscle necrosis.
Materials and methods. Experimental and clinical studies have been carried out on patients with necrosis of the heart muscle.
Results. Patients with necrosis of the heart muscle and depression do not immediately seek medical help, unlike patients without depression. This may affect treatment options (e.g., thrombolysis) and the prognosis in such patients.
Conclusion. Further research is needed to determine whether depression causes inflammation, inflammation causes depression, or if a third, as-yet-unknown pathological process causes both inflammation and depression.
Osteosarcopenia and arterial hypertension: current approaches to the problem
K. Antyukh, E. Grigorenko, А. Sheptulina, O. Drapkina, N. Mitkovskaya
O steosarcopenia is characterized by a combination of low muscle mass (sarcopenia) and reduced bone mineral density (osteopenia/osteoporosis). The results of scientific studies conducted in recent years indicate the existence of a relationship between arterial hypertension, disorders of bone metabolism and / or sarcopenia. In particular, it is known that systemic inflammation, oxidative stress, and insulin resistance are involved in the development and progression of both arterial hypertension and sarcopenia. The same factors may play a role in the pathogenesis of osteopenia and osteoporosis, and the pathological mechanisms underlying the increase in blood pressure, as shown in experimental and clinical studies, can additionally influence the decrease in bone mineral density. This review outlines the current understanding of the diagnosis, epidemiology, etiology, and possible mechanisms of the pathogenesis of osteosarcopenia in patients with arterial hypertension.

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2. Title of the article.

3. Full name of the institutions in which the authors work, indicating the city and country (superscript Arabic numerals indicate the correspondence of the institutions)

4. An abstract in English (1800 to 2500 characters with spaces for original articles, at least 1000 characters for reviews and case reports) should be a brief summary of a large scientific work. It can be published independently from the main text, therefore, it should be understandable without reference to the publication itself. In terms of structure, it is advisable to repeat the sections of the article (for an original articles: purpose, methods, results, conclusion). The text of the abstract should be concise and clear, free of secondary information, superfluous introductory words, and general formulations. The abstract should not contain references to literature. No abbreviations or acronyms other than the commonly used ones should be used. The results of the work are described very accurately and informative. The abstract should contain main theoretical and experimental results, actual data, the relationships and patterns that have been found. Preference is given to new results and data of long-term significance, important discoveries, conclusions that refute existing theories, as well as data that, in the opinion of the author, are of practical importance. Conclusions may be accompanied by recommendations, assessments, suggestions, hypotheses described in the article.

5. Keywords - a set of words that reflect the content of the text in terms of the object, scientific field and research methods; the recommended number of keywords - 5-10.

6. The main text of the article. Depending on the type of manuscript, the structure of the full text may vary. The volume of article including figures, tables, references and abstracts in original articles and case reports should not exceed 30 thousand characters with spaces, in reviews and teaching articles - 45 thousand characters with spaces. Word abbreviations are not allowed except for common abbreviations of chemical and mathematical quantities, measures, terms. The SI system should be used in the articles.

6.1 Original articles  

Original articles contain the results of original research. 

  • Introduction (no more than 2 pages). It should reveal the relevance of the problem that became the subject of the study including its scope (prevalence, morbidity, etc.), mediated effects (social, economic), and identify solved and unsolved aspects of the problem with an analysis of previously published data
  • Purpose of the study 
  • Methods (the section should contain information about the study design, its term, the way of assessing the results of the study, testing the hypothesis of the study with a description of statistical methods and a package for processing the results)
  • Results (a detailed summary of the content and results of the study; if necessary, this section may be divided into subsections)
  • Discussion (the results should be discussed in regard of novelty and compared with known data)
  • Сonclusion (must be presented as a comprehensive text)
  • Source of funding 1 (should specify the source of funding for the performed work)
  • Conflict of interest 2 (the presence of obvious and potential conflicts of interest - conditions and facts that can affect the results of the study or their interpretation)
  • Acknowledgement 3

6.2 Review article

The purpose of a review article is to discuss the accumulated material and present the author's new view of previously described phenomena, rethinking, and searching for new approaches to their interpretation, rather than simply listing the facts and stating the current state of the issue.

Obligatory sections of a review article:

  • Introduction 
  • Discussion (can be isolated in a separate section or run smoothly through the entire text) 
  • Conclusion - (must be presented as a comprehensive text) 
  • Source of funding 1 (should specify the source of funding for the performed work)
  • Conflict of interest 2 (the presence of obvious and potential conflicts of interest - conditions and facts that can affect the results of the study or their interpretation)
  • Acknowledgement 3

1 - you should provide information about the sources of sponsorship in the form of grants, equipment, medicines.

2 - “conflict of interest” refers to the conditions under which people have conflicting or competing interests that can influence an editorial decision. Conflicts of interest can be potential, perceived, and real. Personal, political, financial, scientific, or religious factors may affect objectivity. The author must notify the editor of a real or potential conflict of interest by including information about the conflict of interest in the appropriate section of the article. If there is no conflict of interest the author must also declare it. Sample wording: “The team of authors declares that there is no conflict of interest”. 

3 - in the Acknowledgements section, acknowledgements are given to people who participated in the work on the article, but who are not the authors. Participation in the work on the article implies: recommendations to improve the research, providing space for research, departmental control, receiving financial support, single types of analysis, providing reagents/patients/animals/other materials for the research.

7. References (number of sources should be 25 or less for an original article and 50 or less for reviews) should be compiled according to the Harvard standard (Harvard reference system). Citations in text should be indicated by a number in square brackets (e.g., [1]). References to unpublished works are not allowed. References on sources in Russian should have following structure: authors (transliteration), title of the article in transliterated version [translation of article title into English in square brackets], title of the Russian-language source (transliteration) [translation of source title into English], output data with designations in English. Transliteration of Russian-language titles is performed according to the BSI standard. Examples of formatting of the reference list are listed below. 

References to books: 

  1. Rips L.J. Lines of thought: central concepts in cognitive psychology. Oxford : Oxford Univ. Press, 2011. 441 p.
  2. de Benoist B. et al., eds. Worldwide prevalence of anaemia 1993-2005. WHO Global Database on Anaemia Geneva, World Health Organization, 2008.
  3. Sorokina T.S. Istoriya meditsinyi [History of medicine]. M.: Academia, 2008, 560 p. (in Russian).
  4. Izvekov V.I., Serikhin N.A., Abramov A.I. Proektirovanie turbogeneratorov [Design of Turbo-generators]. Moscow, MEI Publ., 2005, 440 p. (in Russian).

References to journal articles:

  1. George G.W. Vetrovec Hemodynamic Support Devices for Shock and High-Risk PCI:When and Which One. Curr Cardiol Rep. 2017, vol. 19 no.10, pp. 100. doi: 10.1007/s11886-017-0905-3. 
  2. von Drygalski A., Adamson J.W. Ironing out fatigue. Blood, 2011, vol. 118, pp. 3191-3192.
  3. Huo T.I., Lin H.C., Lee S.D. Model for end-stage liver disease and organ allocation in liver transplantation: where are we and where should we go? J Chin Med Assoc, 2006, vol. 69, no. 5, pp. 193-198.
  4. Cholongitas E., Marelli L., Shusang V., Senzolo M., Rolles K., Patch D., Burroughs A.K. A systematic review of the performance of the model for end-stage liver disease (MELD) in the setting of liver transplantation. Liver Transpl, 2006, vol. 12, no. 7, pp. 1049-1061.
  5. Ibanez B., James S., Agewall S., Antunes M.J., Bucciarelli-Ducci C., Bueno H., Caforio A.L.P., Crea F., Goudevenos J.A., Halvorsen S., Hindricks G., Kastrati A., Lenzen M.J., Prescott E., Roffi M., Valgimigli M., Varenhorst C., Vranckx P., Widimský P. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J, 2017, vol. 26. doi: 10.1093/eurheartj/ehx393.
  6. Belov Yu.V., Varaksin V.A. Strukturno-geometricheskie izmeneniya miokarda i osobennosti zentral'noy gemodinamiki pri postinfarktnom remodelirovanii levogo zheludochka [Structural and geometric changes in the myocardium and features of central hemodynamics in postinfarction remodeling of the left ventricle]. Kardiologiya. 2003, vol. 43, no. 1, pp. 19-23. (in Russian).
  7. Mit'kovskaya N.P., Toropilov D.M. Kardiorenal'nyy sindrom pri ostroy ishemicheskoy bolezni serdza [Cardiorenal syndrome in acute coronary heart disease]. Med. zhurnal, 2009, no. 1, pp. 19-23. (in Russian).
  8. Mitkovskaya N., Rummo O., Grigorenko E. Stratifikaziya riska vnezapnoy serdechnoy smerti u rezipientov transplantatov pecheni i pochek [Stratification of the risk of sudden cardiac death in recipients of liver and kidney transplants]. Kardiologiya v Belarusi, 2014, vol. 3, pp. 27-33. (in Russian).

References to articles from collection of articles: 

  1. Pavlyukovskaya E.G. Primenenie pribora spektrofotometr v stomatologicheskoy praktike [Application of the device spectrophotometer in dental practice]. Ctudenty i molodye uchyenye belorusskogo gosudarstvennogo medizinskogo universiteta - medizinskoy nauke i zdravoochraneniyu Respubliki Belarus : sb. nauch. tr. studentov i molodych uchyenych pod red. A. V. Sikorskogo, O. K. Doroninoy. Minsk : BGMU, 2016, pp. 317-320. (in Russian).

Reference to a thesis or dissertation

  1. Ponomareva M.N. Diagnostika i medikamentoznaya korrekziya narusheniy gemodinamiki pri ishemicheskoy neyropatii zritel'nogo nerva u bol'nych s serdechno-sosudistymi zabolevaniyami [Diagnosis and drug correction of hemodynamic disorders in ischemic neuropathy of the optic nerve in patients with cardiovascular diseases] : Diss. dokt. med. nauk : 14.01.07. M., 2010, 235 s. (in Russian).

Reference to patents

  1. Chichkin D.N, Ulaschik V.S., Mit'kovskaya N.P., Mucharskaya Yu.A., Kul'chizkiy V.A. Sposob lecheniya revmatoidnogo artrita [A method of treating rheumatoid arthritis]. Patent BY no 10617, 2006. (in Russian).

V. Information about the authors 

The section is provided at the end of the article and should contain the following information:

  • full name, academic title, degree, position, place of employment
  • working address, and contacts (e-mail, phone numbers, ORCID)

VI. Guidelines on Formatting Tables 

All tables should have a numbered header and clearly marked columns that are easy to read and understand. Table data should correspond to the data in the text but should not duplicate the information presented in it. References to tables in the text are obligatory.

Tables are numbered by arabic numerals in the order of the text. If there is only one table in the text then it is not numbered. The title of the table includes the table number and its name. Alignment of the title – “Left Align”. Title formatting example: Table 1. Scale of risk factors. No dot after the title is required.

Notes to the table are in the same font style and size as the main text (Times New Roman, 12 points), Alignment – “Justify”. Note is placed under the table and must contain the explanation of used abbreviations and other information which is necessary for the interpretation of the data presented in the table.

VII. Guidelines on Formatting Figures

Each figure must be accompanied by a numbered title. References to figures in the text are mandatory. 

Figures are numbered by arabic numerals in the order of the text. If there is only one figure in the text then it is not numbered. The title includes the number and the name of the figure. Alignment of the title – “Center Align”. Title formatting example: 'Figure 1. Normal electrocardiogram'. No dot after the figure title is required. A note to the figure should be in the same font style and size as the main text (Times New Roman, 12 points), Alignment – “Justify”, placed under the figure title and must contain the explanation of used abbreviations and other information which is necessary for the interpretation of the data presented in the figures.

Illustrations (graphs, diagrams, schemes, drawings) drawn with MS Office tools should be contrast and clear. Illustrations should be made in a separate file and saved as an image (in *.jpeg, *.bmp, *.gif format), and then placed in the manuscript file as a fixed figure. It is unacceptable to put any elements (arrows, captions) over the figure inserted in the manuscript file by means of MS WORD due to the great risk of their loss at the stages of editing and layout.

Photographs, screenshots, and other non-drawn illustrations should not only be inserted in the text of the manuscript but also uploaded separately as *.jpeg, *.bmp, *.gif files (*.doc and *.docx - in case additional marks are put on the image). The resolution of the image should be >300 dpi. The image files should be given a name corresponding to the number of the figure in the text.

Checklist for Preparing Material for Submission

Authors must acknowledge the following items to submit an article. The manuscript may be returned to the authors if it does not match them:

  1. The article has not been previously published nor it has been submitted for review and publication in another journal.
  2. The file of the submitted article is in Microsoft Word document format with figures and tables placed in the text after the references to them, i.e., all the information is submitted in one file.
  3. Full web addresses (URLs) for references are given where it is possible.
  4. The text is typed with the following parameters: font style – Times New Roman, font size – 12 points, line spacing 1,5, paragraph indent 12,5 mm, no word hyphenation. Margins: upper and bottom - 25 mm, left - 30 mm, right - 10 mm. All pages must be numbered; all illustrations, graphs and tables are placed in appropriate places in the text, not at the end of the document.
  5. The text complies with the stylistic and bibliographic requirements described in the 'Rules for Authors'.

The order of reviewing article manuscripts submitted to the scientific and practical peer-reviewed journal “Emergency Cardiology and Cardiovascular Risks”

Manuscripts of all scientific articles submitted to the editors are subject to mandatory review by two independent experts. Review is carried out by the scientists who are recognized experts in the field of reviewed materials and work in the field of knowledge to which the content of the manuscript belongs and who have had publications on the subject of the article under review over the last three years.

The author, supervisor of a scientific degree scholar or coauthors of the reviewed work cannot be reviewers. The review of a scientific article is issued in accordance with the Memo to the reviewer of scientific articles and materials submitted to the journal “Emergency Cardiology and Cardiovascular Risks”.

Manuscripts are not considered for publication in case they do not meet the “Rules for Authors” which are published for convenience in the journal and its electronic version.

The editor informs the author about the review result by providing a copy of the review. The review contains recommendations for publication, correction and improvement of the article or a reasonable refusal. The author of the manuscript may take into account the recommendations when preparing a new version of the article or reasonably refute them. Articles refined by the author are resubmitted for review by a reviewer who made critical comments. The incoming date is considered to be the date of the refined article submission. If the author disagrees with the reviewer's comments, he may apply for a second review engaging a third expert or withdraw the article.

Articles and article reviews are discussed at the meeting of the editorial board, which serves as a basis to accept or reject an article. The decision of the editorial board is registered in by the protocol.

The order and priority of publications are determined depending on the volume of published materials and the list of subdivisions in a particular issue.

The editorial board does not guarantee the publication of all submitted materials. The article will not be accepted for consideration if it has been published or sent to other journals, the authors have not provided their complete personal data or the article does not meet the “Rules for Authors”. The editors reserve the right to edit the article without notifying the authors.

The final decision on the expediency of publications after their reviewing is made by the editorial board.

Articles not allowed for publication:

  • manuscripts which are not related to the scientific area of the journal;
  • manuscripts which do not meet the design requirements and their authors refuse to make their technical refinement;
  • manuscripts, the authors of which did not change the article according to the constructive requirements of the reviewer;

manuscripts, representing significant plagiarism due to copying data or conclusions from another author’s research without proper citation/reference (according to the recommendations of the World Association of Medical Editors (WAME) and COPE (Committee on Publication Ethics)); resubmission of the publication under the name of another author (in the original language or in translation); verbatim copying of more than 100 words from another (including his own) publication in the absence of a properly arranged quotation; unpublished borrowings of previously published ideas or hypotheses of other authors, and/or those that have not been tested by the “Anti-plagiarism” Automatic Text Checking System for borrowing from publicly available information sources.

If plagiarism is suspected:

the editorial board informs the experts and the author(s) of the material in writing about the initiation of the editorial investigation and its expected timeframe (2 months). Based on the results of the editorial investigation, a written statement is drawn up (stored in the editorial office), copies of which are provided to the person who discovered the fact of plagiarism and the author(s) about the decision made and the undertaken actions.

In case of insignificant plagiarism the editors of the journal must notify the author about the fact of plagiarism and obtain written explanations. If a violation by the author is qualified as unintentional, confine to a reprimand and sending a message about the inappropriateness of repeated cases. A revised manuscript with references to all original sources of borrowing may be published.

Manuscripts and electronic versions of both published and unpublished materials are not returned.

Reviews are kept in the editorial office for five years.

About Us

ISSN 2616-633X

Publishing semi-annual
Articles in Russian. Summaries in English

Address:

Dzerzhinski Ave., 83, Minsk, Republic of Belarus, 220116
Tel: +375 17 277-12-01.
Fax: +375 17 277-12-02
E-mail:  emcardio@bsmu.by
Web-site:  https://emcardio.bsmu.by

Editor-in-chief: Prof. Natalya P. Mitkovskaya, MD, PhD. Educational Institution «Belarusian State Medical University», Minsk, Belarus

Executive Secretary: Ekaterina B. Petrova, PhD Educational Institution «Belarusian State Medical University», Minsk, Belarus

Executive Editorial Office Secretary: Olga V. Laskina. Educational Institution «Belarusian State Medical University», Minsk, Belarus

 

Editor-in-chief greeting

 

Publication Ethics

Editorial Board

Sikorskij A.V., PhD in Medical sciences, Associate Professor  (Minsk, Belarus)
Vojtovich T.N., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Gelis L.G., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Gubkin S.V., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Danilova L.I., Grand PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Dzjadz`ko A.M., Grand PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Karpov I.A., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Kirkovkij V.V., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Kozlovkij V.i., Grand PhD in Medical sciences, Professor (Vitebsk, Belarus)
Kopitov A.V., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Ostrovskij Ju.P. A.Yu., PhD in Medical sciences, Associate Professor  (Minsk, Belarus)
Petrova M.N., PhD in Philological sciences, Associate Professor  (Minsk, Belarus)
Pristrom A.M., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Rudenko E.V., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Rudenok V.V., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Ruzanov D.Yu., PhD in Medical sciences, Associate Professor (Gomel, Belarus)
Salivonchik D.P., Grand PhD in Medical sciences, Professor (Gomel, Belarus)
Sidorovich E. K., Grand PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Sudzhaeva O.A., Grand PhD in Medical sciences (Minsk, Belarus)
Uss A.L., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Tsapaeva N.L., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Yanushko A.V., PhD in Medical sciences, Associate Professor (Grodno, Belarus)

 

Advisory Editorial Board

(International Consultative Committee)

Abel`skaya I.S., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Khryshchanovich V.Ya., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Azimferey Leonhard, Grand PhD in Medical sciences, Professor (Tîrgu Mureș, Romania)
Arutjunov G.P., Corresponding Member of the Russian Academy of Sciences , Grand PhD in Medical sciences, Professor (Moscow, Russian Federation)
Bedel'baeva G.G., Grand PhD in Medical sciences, Professor (Almaty, Kazakhstan)
Beljaeva L.N., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Vismont F.I., Corresponding Member of the National Academy of Sciences o Belarus , Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Dzhunusbekova G.A., Grand PhD in Medical sciences, Professor (Almaty, Kazakhstan)
Drapkina O.M., Corresponding Member of Russian Academy of Sciences , Grand PhD in Medical sciences, Professor (Moscow, Russian Federation)
Dudarenko S.V., Grand PhD in Medical sciences, Professor (St. Petersburg, Russian Federation)
Kamilova U.K., Grand PhD in Medical sciences, Professor (Tashkent, Uzbekistan)
Kibira Satoshi, Grand PhD in Medical sciences, Professor (Akita, Japan)
Koziolova N.A., Grand PhD in Medical sciences, Professor (Perm, Russian Federation)
Kostjuk William, Grand PhD in Medical sciences, Professor (London, Canada)
Krasnyj S.A., Corresponding Member of the National Academy of Sciences of Belarus, Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Kubarko A.I., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Kul'chickij V.A., Corresponding Member of the National Academy of Sciences of Belarus,  Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Linn Tommi, Grand PhD in Medical sciences, Professor (Stockholm, Sweden)
Mrochek A.G., Academician of the National Academy of Sciences of Belarus,  Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Oganov R.G., Academician of the Russian Academy of Sciences,  Grand PhD in Medical sciences, Professor (Moscow, Russian Federation)
Ostrovskij Ju.P., Academician of the National Academy of Sciences of Belarus,  Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Pershagen Joran, Grand PhD in Medical sciences, Professor (Stockholm, Sweden)
Pinevich D.L., First Deputy Minister of Health of the Republic of Belarus (Minsk, Belarus)
Rebrov A.P., Grand PhD in Medical sciences, Professor (Saratov, Russian Federation)
Rud Charls, Grand PhD in Medical sciences, Professor (Berkeley, USA)
Rummo O.O., Corresponding Member of the National Academy of Sciences of Belarus, Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Skugarevskij O.A., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Snezhickij V.A., Corresponding Member of the National Academy of Sciences of Belarus, Grand PhD in Medical sciences, Professor (Grodno, Belarus)
Sukalo A.V., Academician of the National Academy of Sciences of Belarus,  Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Tiffi Patrik, Grand PhD in Medical sciences, Professor (London, Canada)
Tret'jak S.I., Corresponding Member of the National Academy of Sciences of Belarus, Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Fedoruk A.M., Grand PhD in Medical sciences, Professor (Minsk, Belarus)
Hirmanov V.N., Grand PhD in Medical sciences, Professor (St. Petersburg, Russian Federation)
Zhebentyayev A.I., Grand PhD in Pharmaceutical Sciences, Professor (Vitebsk, Belarus)
Gurina N.S., Grand PhD in Biological sciences, Professor (Minsk, Belarus)
Tsarenkov V.M., Grand PhD in Pharmaceutical Sciences, Professor (Minsk, Belarus)
Khishova O.M., Grand PhD in Pharmaceutical Sciences, Professor (Vitebsk, Belarus)
Kuznetsov V.A., Grand PhD in Medical sciences, Professor (Tyumen, Russian Federation)

 

Publishing Group

Balysh E. M., PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Rachok L.V., PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Volod'ko Ju.S., PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Gerasimenok D.S., PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Grigorenko E.A., PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Mazanik Ju.N., (Minsk, Belarus)
Martusevich N.A., PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Pyko A.A., PhD in Medical sciences (Minsk, Belarus)
Rustamov M.N., PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Skakun L.N., (Minsk, Belarus)
Statkevich T.V., PhD in Medical sciences, Associate Professor (Minsk, Belarus)
Tenjushko E.S., (Minsk, Belarus)
Lanushevskaia A.V., (Minsk, Belarus)
Korzhenevskaia Iu.V., (Minsk, Belarus)
Tkachyova O.A., design, computer layout (Minsk, Belarus)
Vinokurov V.F., design, computer layout (Minsk, Belarus)
Zhuk L.I., editor (Minsk, Belarus)