Latest Tables of Contents with Summaries

2024 Том 8, №2
STEP-BY-STEP diagnosis of cardiac amyloidosis: from suspicion to verification
A.A. Bondareva, E.M. Balysh, T.V. Statkevich, E.B. Petrova, O.M. Shabunevich, D.S. Moiseenko, N.B. Kononchuk
The article analyzes the modern view on the algorithm for the diagnosis of amyloid cardiomyopathy and the role of cardiovascular magnetic resonance imaging in it. A step-by-step diagnosis of AA amyloidosis of the heart is presented using a clinical case as an example. The course of the disease was characterized by worsening of the symptoms of heart failure in combination with persistent increase in troponin levels, pseudo-infarction pattern on the electrocardiogram, and unexplained myocardial hypertrophy according to echocardiography. In order to clarify the nature of the myocardial damage, a cardiovascular MRI was performed, the results of which revealed signs of storage disease. In order to confirm amyloidosis, a histological examination of a biopsy of the oral mucosa was performed.
Level of P-selectin and integrin-β3 in blood plasma of patients with stenotic atherosclerosis of coronary arteries
A. Chernyak, V A. Snezhitskiy, A V. Yanushka, V. R. Shulika
Introduction. The problem of stenotic atherosclerosis remains one of the leading causes of morbidity and mortality worldwide, significantly impacting healthcare systems and patient quality of life. This disease is characterized by the accumulation of atheromatous plaques in the arterial walls, leading to their narrowing and eventual obstruction of blood flow. Major risk factors include hyperlipidemia, hypertension, diabetes mellitus, and smoking.
The pathogenesis of atherosclerosis is multifactorial, involving complex interactions between lipid metabolism, inflammatory processes, endothelial dysfunction, and genetic predispositions. Diagnosis and treatment of atherosclerosis include both non-invasive imaging techniques and invasive procedures such as percutaneous coronary intervention (PCI). Personalized medicine and new biomarkers play a crucial role in improving treatment outcomes.
Aim of the Study. To determine the levels of biochemical markers (P-se-lectin and integrin-β3) in the plasma of patients with ischemic heart disease (IHD) who underwent PCI, in order to assess their potential as predictors of the development of coronary artery stenosing atherosclerosis.
Materials and Methods. The study was conducted at the Grodno Regional Clinical Cardiology Center from 2017 to 2023. The study included 209 patients, divided into three groups:
– Group 1 (n = 31) – healthy individuals.
– Group 2 (n = 30) – patients with chronic ischemic heart disease without indications for invasive coronary angiography (CAG).
– Group 3 (n = 148) – patients with ischemic heart disease who underwent invasive coronary angiography and percutaneous coronary intervention (PCI).
Plasma levels of P-selectin and integrin-β3 were measured using enzyme-linked immunosorbent assay (ELISA). Statistical data analysis was performed using the STATISTICA 10.0 software package.
Results. Key clinical and anamnestic data showed significant differences between patient groups in terms of age, body mass index, blood pressure, and the presence of comorbidities. Levels of integrin-β3 and P-selectin were significantly higher in Group 3 compared to Group 2 and Group 1, respectively. This indicates higher inflammatory activity in patients with clinically significant stenotic atherosclerosis.
Conclusions. Our study revealed differences in the clinical and anamnestic characteristics and the levels of integrin-β3 and P-selectin markers between groups of patients who developed clinically significant coronary artery atherosclerosis and those who, due to stenotic atherosclerosis, underwent PCI.
Microcirculation (part 3 – methods of microcirculation assessment)
N.L. Tsapaeva, V.G. Tsapaev
Microcirculatory dysfunction is one of the determining risk factors for the development of myocardial ischemia. Microcirculation disorders are diverse in pathogenesis and clinical manifestations. Therefore, it is necessary to have information not only about the state of blood flow at the tissue level, but also to have the ability to monitor it during long-term observation. In this regard, the determination of diagnostically informative quantitative and qualitative parameters of microcirculatory blood flow is one of the urgent problems in the management of internal diseases. The article considers three main groups of methods for studying microcirculation: 1-visualizing methods (computer microscopy of the vessels of the nail bed of the upper and lower extremities, bulbar conjunctiva, mucous membrane of the oral cavity); 2-clinical and metric studies (laser Doppler flowmetry, high-frequency ultrasound Dopplerography); 3-methods that determine blood flow and gas exchange at the level of microcirculation (radionuclide methods of research, positional emission tomography, non-invasive oximetry). The article describes specific methods of implementation, the most informative indicators and parameters of each technology, which allow assessing the degree of microcirculatory disorders and control the effectiveness of the treatment, and analyses the advantages and disadvantages of the presented methods of microcirculation research.
Effectiveness of complete and incomplete myocardial revascularization in the long-term period of acute coronary syndrome with ST segment elevation
N.L. Tsapaeva, E.V. Burakovskaija, S.F. Zolotuhina, M.G. Kolijadko, I.I. Russkih, A.М. Korotkin, P.A. Luhautsova
Objective. To assess the functional adequacy of emergency X-ray endovascular myocardial revascularization (RERM) in the late period of acute coronary syndrome. To determine clinical, biochemical and microcirculatory markers of high cardiovascular risk during 6 months of observation.
Materials and methods. A total of 54 patients were examined in 6 months after primary percutaneous coronary intervention for acute coronary syndrome (ACS): 24 with complete myocardial revascularization and 30 with incomplete myocardial revascularization. The study methods included: assessment of the dynamics of biomarkers associated with high cardiovascular risk (enzyme-linked immunosorbent assays); monitoring of the effectiveness of dual antithrombotic therapy (Multiplate); a 6-minute walk test; ejection fraction (EF); a study of the state of microcirculation by computer conjunctival biomicroscopy (CBM); oxygen utilization and transport by noninvasive oximetry;
Results. All patients examined with standard DAPT achieved an adequate antiplatelet effect. In the group of patients with complete RERM, there was a significant improvement in all the studied parameters. Analysis of the dynamics of the studied parameters and the clinical status in the group of patients with incomplete ERRM showed that after 6 months of observation the effectiveness of the technology can be assessed as functionally adequate in 73.3% of patients. Incomplete functionally inadequate RERM was associated with a significant decrease in the number of functioning capillaries (FC) according to the GBM data; a decrease in the partial pressure of oxygen in the tissue (PO2), the rate of utilization (V1), the rate of oxygen tension recovery (V2) and, accordingly, lower capillary blood flow (LP), according to non-invasive oximetry, which corresponded to the clinical criteria of low quality of life (need for nitrates, low tolerance to physical activity). As a result of the study, we determined biochemical (CRP > 10 mg/l; ST2 > 35 ng/ml; NTproBNP > 200 pg/ml; TIMP-1 > 388 ng/ml) and microcirculatory (FC > 3 points; LP > 0.75 mmHg/sec) markers of high cardiovascular risk.
Conclusion. The functional adequacy of incomplete revascularization in the late period of ACS is due to the presence of viable myocardium in the zone of chronic occlusion and the formation of effective retrograde reperfusion. It was found that after 6 months of observation 73.3% of patients with ACS had effective restoration of blood supply, confirmed by a reliable improvement in clinical status, dynamics of biomarker levels, microcirculation parameters and oxygen kinetics parameters. The totality of the markers of cardiovascular risk presented in the results of the study in patients with ACS in the long-term period requires prompt resolution of the issue of surgical correction of the coronary bed if aortocoronary bypass grafting is technically possible.
Determinants of recurrent ischemic events within 30 days in patients with acute myocardial infarction
T.P. Pronko, V.A. Snezhitskiy, S.A. Lialikau
Aim. To identify the determinants of recurrent ischemic events within 30 days in patients with acute myocardial infarction (MI).
Methods. The prospective observational study included 405 patients, divided into 2 groups based on endpoints. Group 1 included 369 people without events; group 2 included 36 patients with recurrent ischemic events (stent thrombosis, recurrent myocardial infarction, peri-infarction angina). The following studies were performed: multielectrode aggregometry, blood test with platelet indices, enzyme-linked immunosorbent determination of soluble CD40 ligand, sP-selectin, von Willebrand factor and endothelin-1 on days 1–2 of MI, genotyping of CYP2C19, P2RY12, ITGB3, ITGA2, eNOS3 genes.
Results. Using step-by-step discriminant analysis, the following equation was constructed: Y = –15,9829 + 0,0211 × X1 + 0,0777 × X2 + 1,1012 × X3 + + 0,0183 × X4++0,1002 × X5 + 0,0455 × Х6 + 0,1653 × Х7 + 0,5568 × Х8 + + 0,1546 × Х9 + 0,3175 × Х10, where: Х1 – age, years; X2 – waist circumference, cm; X3 – NYHA FC; X4 – erythrocyte sedimentation rate in a blood test, mm/h; X5 – the number of leukocytes in a blood test; X6 – ADP-test (U) value of the aggregogram; X7 – fibrinogen level (g/l) in blood plasma; X8 – results of genotyping of the polymorphic marker G681A (*2) of the CYP2C19 gene, where carriage of genotype GG = 0, carriage of genotype GA = 1, carriage of genotype AA = 2; X9 – results of genotyping of the C807T polymorphic marker of the ITGA2 gene, where carriage of genotype CC = 0, carriage of genotype ST = 1, carriage of genotype TT = 2; X10 – results of genotyping of the T786C polymorphic marker of the eNOS3 gene, where carriage of the TT genotype = 0, carriage of the TC genotype = 1, carriage of the CC genotype = 2. If Y > 0, the probability of developing recurrent ischemic events within 30 days from the onset of MI is high. If Y ≤ 0, the probability of developing recurrent ischemic events within 30 days from the onset of MI is low. The diagnostic sensitivity of the model is 77.7%, diagnostic specificity is 80.0%, accuracy is 77.9%, the predictive value of a negative result (favorable prognosis) is 97.6%, the predictive value of a positive result (unfavorable prognosis) is 25.3 %.
Conclusions. Short-term prognosis is influenced by age, abdominal obesity, inflammation and insufficient efficacy of clopidogrel, carriage of mutant alleles of the CYP2C19, ITGA2 and eNOS3 genes, the products of which affect the metabolism of clopidogrel and platelet activity.
Noninvasive diagnosis of preclinical stages of coronary and precerebral atherosclerosis in patients with newly diagnosed hypo- and hyperthyroidism
E.B. Petrova, O.N. Shishko, E.A. Grigorenko, T.V. Statkevich, A.A. Pleshko, S.V. Chernyak, I.A. Kozich, A.A. Pichugina, S.V. Gunich, S.А. Makhnach, N.P. Mitkovskaya
According to WHO data, cardiovascular diseases account for 63% of total mortality from non-communicable diseases worldwide, with the largest share of deaths attributed to ischemic heart disease (IHD) and stroke. Untimely detection of preclinical stages of atherosclerosis in comorbid patients leads to delayed initiation of preventive pharmacological and non-pharmacological therapy.
The need to develop and implement a diagnostic algorithm for atherosclerosis of coronary and precerebral arteries in patients with hypo- and hyperthyroidism in clinical practice is driven by the widespread prevalence of thyroid pathology in the Republic of Belarus and globally. This is due to the development of severe cardiovascular complications in the absence of adequate preventive measures, early disability of patients, high financial costs of interventional and cardiac surgical diagnostic and treatment procedures, and the necessity to ensure more rational use of budget funds for outpatient and inpatient treatment, as well as reducing expenses related to loss of working capacity due to cardiovascular diseases in individuals with thyroid dysfunction.
Objective of the study: to evaluate the potential of a diagnostic algorithm for atherosclerosis of coronary and precerebral arteries at the preclinical stage in patients with hypo- and hyperthyroidism for inclusion in a set of medical services aimed at providing care to comorbid patients with thyroid pathology and atherosclerosis-associated circulatory system diseases.
Materials and Methods. The study included 118 working-age patients with thyroid diseases newly diagnosed with hypo- or hyperthyroidism without clinical signs and history of IHD and chronic cerebral circulation insufficiency. Examination of asymptomatic patients with hypo- or hyperthyroidism included analysis of clinical and anamnesis data (complaints, anamnesis, objective examination with blood pressure measurement and making an anthropometric passport of the patient), biochemical blood test with lipid spectrum interpretation and determination of the type of hyperlipidemia according to the WHO classification, and instrumental data (transthoracic echocardiography, volumetric sphygmography with determination of CAVI and ABI indices, ultrasound of brachiocephalic arteries (BCA), cardiac computed tomography with coronary calcium screening programs and CT coronary angiography (CT-CAG)).
Results. Atherosclerotic lesions of BCA were detected in 58.5% of individuals with hypothyroidism and 28.8% with thyroid hyperfunction with a multi-vessel lesion rate of 34.0% and 12.5%, and one or a combination of several signs of atherosclerotic plaque (ASP) instability in 41.5% and 4.2% of patients with hypo- and hyperthyroidism respectively. Atherosclerosis of coronary arteries was verified in 44.6% of examined patients with hypothyroidism and 20.0% with hyperthyroidism, with multi-vessel (2 or more) coronary artery lesions in 36.1% and 3.1% of individuals with hypo- and hyperthyroidism respectively. All patients included in the study with instrumentally confirmed atherosclerosis were prescribed lipid-lowering therapy with statins. Hemodynamically significant stenosing lesion (ASP > 50%) according to CT-CAG was detected in 4.8% of asymptomatic patients with hypothyroidism and in 1 patient with hyperthyroidism. Selective percutaneous coronary artery angiography was performed on 5 asymptomatic patients with different thyroid hormone statuses resulting in percutaneous coronary intervention with the implantation of 2 or more coronary stents in three patients with hypothyroidism and coronary artery bypass grafting in a patient with hypothyroidism and a patient with hyperthyroidism due to multi-vessel atherosclerotic lesions with ASP over 85–90%.
Conclusion. The diagnostic algorithm for atherosclerosis of coronary and precerebral arteries in patients with hypo- and hyperthyroidism can be recommended for quickly determining the optimal diagnostic approach for detecting asymptomatic stages of atherosclerosis in various locations. It is particularly useful for diagnosing atherosclerosis in the coronary and precerebral arteries in patients with either hypo- or hyperthyroidism. The algorithm is designed to be safe for both doctors and patients, cost-effective, and easy to implement in different regions of the Republic of Belarus and internationally. Implementing this algorithm will enhance the quality of medical care for patients with comorbid conditions and help decrease the incidence of atherothrombosis in the coronary and precerebral arteries among the Belarusian population. It will also aid in defining both pharmacological and non-pharmacological strategies for preventing cardiovascular events in individuals with varying thyroid hormone statuses.
Conflict of interest: the authors declare no conflict of interests.
Contribution of the authors: Petrova E.B. – concept and design of the article, collection of materials, processing, writing of the text; Shishko O.N., Grigorenko E.A., Statkevich T.V., Kozich I.A., Pichugina A.A., Gunich S.V., Makhnach S.A., Chernyak S.V. – collection and processing of materials; Pleshko A.A. – collection of materials and preparation of the text for publication; Mitkovskaya N.P. – concept of the article, analysis of the obtained data, editing.
Funding source. The study was conducted within the Research and Development framework under task 02.32 “To develop and implement a method for predicting the development of atherosclerosis in patients with hypo- and hyperthyroidism” of the subprogram “Cardiology and Cardiac Surgery” under the guidelines of the state scientific and technical program “Scientific and technical support of quality and availability of healthcare services”, 2021–2025. The authors did not receive financial support from drug and medical device manufacturing companies.
Intestinal microflora of normotensive patients with visceral obesity
E. Sukhotskaya, Y. Malinovskaya, P. Semizhon, M. Chernevskaya, M. Belskaya, O. Pavlova
Weobtained changed readings in the quantitative composition of certain representatives of the intestinal microflora characteristic of normotensive patients with visceral obesity in comparison with normotensive patients without visceral obesity. They included a decreased pool of commensal bacteria Faecalibacterium spp. (10.51 ± 1.13 vs. 9.5 ± 1.14, p = 0.020), Lactobacillus spp. (9.17 ± 1.74 vs. 8.00 ± 2.52, p = 0.025), Bacteroides spp. (9.02 ± 0.76 vs. 8.46 ± 0.47, p = 0.027), Fusobacterium spp. (13.4 ± 1.01 vs. 12.03 ± 0.92, p < 0,001), Bifidobacterium spp. (7.31 ± 1.16 vs. 5.95 ± 1.82, p = 0.028) respectively. Quantitative content of representatives of opportunistic intestinal microflora Streprococcus spp. (6.31 ± 0.79 vs. 5.87 ± 0.78, p = 0.032) and Staphylococcus spp. (6.67 ± 1.23 vs. 5.98 ± 0.98, p = 0.036) was increased in patients with visceral obesity compared to the group of patients without visceral obesity.
Modern approaches to cardiovascular risk stratification in patients with diabetes mellitus
V.L. Lobashova, A.A. Kachan, А.А. Pichugina, I.V. Pateyuk
The problem of cardiovascular diseases (CVD) remains the focus of close attention of physicians of various specialties. Given the prevalence of diabetes mellitus (DM), as well as the high risk of developing macro- and microvascular complications, the issue of preventing cardiovascular pathology in individuals with DM is extremely relevant. Such patients have many risk factors, are characterized by an unfavorable prognosis and high rates of disability and mortality. Reducing the risk of cardiovascular diseases in DM is an important medical and social aspect that should be given priority attention. Timely detection of risk factors and implementation of primary prevention measures will help reduce premature mortality, improve the quality of life of patients and reduce the economic burden of the disease. SCORE2-Diabetes is a new algorithm for assessing the 10-year risk of cardiovascular disease in patients with diabetes mellitus, which is designed to improve the accuracy of identifying people at high risk of developing cardiovascular pathology in Europe.
Anthropometric and structural and functional parameters of the cardiovascular system in polymorphisms of the angiotensin-converting enzyme gene and endothelial nitric oxide synthase in the context of complex treatment of breast cancer
N. Kananchuk
Aim. To evaluate the influence of the polymorphisms of genes encoding the activity of angiotensin-converting enzyme (ACE, I/D polymorphism, rs4343) and endothelial nitric oxide synthase (NOS, T/C polymorphism, rs 2070744; G/T polymorphism, rs 1799983) on anthropometric and structural and functional indicators of the cardiovascular system in patients undergoing breast cancer combined treatment.
Methods. We evaluated the cardiovascular health of 50 women who received combined treatment of breast cancer. 44 patients were divided into three groups, depending on the polymorphisms of genes. In the study, all women received a comprehensive evaluation of the cardiovascular health at the beginning and at the end of breast cancer treatment.
Results.The data obtained indicate that the presence of the ACE gene allele D (rs 43) in the patient (polymorphism I/D and D/D) determines the predisposition to an increase in weight and body mass index following antitumor therapy; an increase in volume parameters and linear dimensions of the left ventricle, a decrease in the ejection fraction and a change in left ventricular remodeling parameters, disorders of relaxation processes and systolic function of the right ventricle, increased activity of the sympathetic nervous system, lower indicators of endothelium-dependent dilation of the brachial artery before the start of antitumor therapy.
The detection of the G allele of the nitric oxide synthase gene (G/T, rs 1799983) (G/G, G/T polymorphisms) in patients receiving complex breast cancer treatment indicates a predisposition to the following changes: weight gain, body mass index, waist and hip size. The presence of the G allele predisposes to a decreased ejection fraction, left ventricular remodeling processes, deterioration of diastolic function of the left and right ventricles, activation of the sympathetic nervous system and the negative effects of antitumor treatment on the structure of the endothelium and its function.
The C allele of the nitric oxide synthase gene (polymorphisms C/C, T/C) in patients receiving complex breast cancer treatment, determines a predisposition to weight gain, body mass index, decrease in ejection fraction and the development of left ventricular remodeling by the end of antitumor therapy.
Conclusion. Despite the limited use of medical genetic examination in routine clinical practice, the study substantiated the determination of polymorphisms of the angiotensin-converting enzyme gene (rs 4343, polymorphism I/D) and nitric oxide synthase (polymorphisms T/C, rs 2070744 and G/T, rs 1799983) to identify individual predisposition to the development of cardiovascular complications of antitumor therapy for breast cancer.
Selection of medical rehabilitation methods for patients after myocardial revascularization combined with low back pain
L. Kabylka, N. Halinouskaya, Y. Tabanjkova, N. Nikalaeva, E. Tsitko, M. Paltsava
Objective. To develop a differentiated program of medical rehabilitation for patients after myocardial revascularization associated with neurological manifestations of intervertebral disc damage.
Materials and methods. A cohort study of 55 (48 males and 7 females) patients after myocardial revascularization combined with neurological manifestations of intervertebral disc damage (mean age 60 [64; 66] years) was performed. Patients underwent clinical examination, functional tests, and laboratory examination. All patients were divided into groups randomly. In the main group, a method of medical rehabilitation based on the division of patients according to the combination of cardiogenic and vertebrogenic pain syndrome severity was applied.
Results. The use of the method of differentiated medical rehabilitation based on the gradation of pain syndrome revealed more significant functional improvement (limitation of life activity in the category of ability to work 35% and 98%, p = 0.004), subjectively (according to VAS, cardiogenic pain syndrome 1.9 and 0.65 points, p < 0.01; vertebrogenic pain syndrome 3.5 and 1 point, p < 0.001). Stabilization of systolic blood pressure after rehabilitation was found in the lower range of 130 [120; 140] and 120 [110; 120] mm. Hg., p < 0.01.
Conclusion. Application of the method of differentiated medical rehabilitation taking into account the combination of pain syndrome of cardiogenic and vertebrogenic genesis revealed a more significant improvement of the patients’ condition.
The frequency and structure of complications of surgical treatment of atrioventricular block in children
V.O. Kadochkin, K.V. Drozdovsky, Yu.I. Linnik, A.S. Garipov, V.G. Koblik, E.V. Zasim
Aim: to carry out a retrospective analysis of the frequency and structure of complications of surgical treatment of atrioventricular block in children treated at the RSPC of pediatric surgery in the period from 2012 to 2023 and to study the effectiveness of the algorithm of surgical treatment of atrioventricular block (AV block) to prevent postoperative complications associated with the implantation of an electrocardiostimulator.
Materials and methods. The analysis of the frequency and structure of complications of surgical treatment of AV block in children was carried out by retrospectively examining the medical records of 272 patients who underwent implantation of an electrocardiostimulator (ECS) in the RSPC for Pediatric Surgery in the period from 2012 to 2023.
Results and discussion. It was noted that the frequency of all postoperative complications associated with the implantation of the ECS was 18.7%. In the structure of complications, the most frequent were: electrode dysfunction requiring its replacement (80.2%), infectious complications (9.6%), ECS-induced cardiomyopathy (7.7%). Electrode dysfunction occurred 2.1 times more often with endocardial access. Epicardial right ventricular stimulation increased the risk of developing ECS-induced cardiomyopathy. Since 2018, using the algorithm of surgical treatment of AV block developed by us, the overall frequency of postoperative complications in children has decreased from 22% to 15%, i.e. by 1.5 times, and the risk of developing ECS-induced cardiomyopathy with epicardial stimulation has been eliminated.
Conclusion. The analysis showed that pacing in children is associated with a high risk of complications. Their frequency and structure depend on the correct access, taking into account the patient’s weight and the focus of stimulation. The use of the algorithm of surgical treatment of AV block in children developed by us reduces the overall frequency of postoperative complications and the risk of developing ECS-induced cardiomyopathy.
Ischemic heart disease: the impact of otorhinolaryngological pathology on the patients’ quality of life
P.A. Zatoloka, E.S. Tarasik, N.V. Zatoloka, O.I. Rodionova
Assessment of the quality of life is a simple and reliable method for assessing the general well-being of a person, which is useful in assessing the clinical and social effectiveness of various methods of prevention, treatment and rehabilitation.
Objective. To determine the impact of chronic pathology of the ear, pharynx, nose and larynx on the quality of life of patients suffering from chronic ischemic heart disease.
Material and methods. The study involved 103 patients who were hospitalized in the healthcare institution “4th City Clinical Hospital named after N.E. Savchenko” of Minsk. The survey was conducted using the general questionnaire SF-36. The inclusion criteria for the study were chronic ischemic heart disease and chronic otolaryngological pathology. Results. Chronic diseases of the ear, throat, nose and larynx in combination with chronic ischemic heart disease have a significant impact on the quality of human life, causing a decrease in the value of the integral indicator of the physical component of health to 64.7±13.2 and the psychological component of health to 60.1±13.1. The most significant emotional impact on the quality of life of a person is provided by the combination of chronic ischemic heart disease with chronic pharyngeal pathology, which is confirmed by the maximum gap between the indicators of the physical component of health (75.2 ± 10.3) and psychological (62.2±13.7), which amounted to 13 points.
Conclusion. Chronic diseases of the nose and paranasal sinuses have the most significant negative impact on the quality of life of patients with chronic ischemic heart disease (PH – 60.2±13.8, MH – 51.3±11.7), namely, chronic polypous rhinosinusitis (PH – 61.0±11.2, MH – 50.3±10.6) and chronic purulent rhinosinusitis (PH – 57.1±13.6, MH – 47.6±13.1).
Podocin as an early biomarker of atherosclerosis in patients with type 2 diabetes mellitus
V. Vasilkova, T. Mokhort, I. Pchelin, N.A. Pervyshin, Y.A. Borovets
Introduction. Diabetic nephropathy, on the one hand, is one of the most common causes of end-stage chronic kidney disease in diabetes mellitus (DM), and on the other hand, a risk factor for the development of cardiovascular complications. Microalbumin has traditionally been used in routine practice to assess renal function and cardiovascular risk, however, many markers are now being identified that are associated with renal dysfunction, one of which is podocin. In this regard, it becomes relevant to study podocin in order to predict the risk of developing cardiovascular diseases in diabetes in the future.
Purpose. To study the relationship between podocin levels and atherosclerotic arterial lesions in patients with type 2 diabetes.
Materials and methods. The study included 316 patients with type 2 diabetes, median age 66.00 [60.00; 72.00] years. The investigation of patients included a standard examination with assessment of podocin levels in urine and ultrasound examination of the brachiocephalic arteries with determination of intima-media thickness (IMT) of the common carotid artery (CCA).
Results. Podocin levels in patients with DT2 were significantly higher compared to the control group (0.615 [0.320; 1.892] vs. 0.240 [0.140; 0.300] ng/ml, p < 0.001). When conducting a correlation analysis of the relationship between podocin and IMT CCA, we established a close direct relationship (r = 0.524 for IMT on the right and r = 0.518 for IMT on the left with p < 0.001). Using the binary logistic regression method, a significant association of podocin with IMT CCA was determined, so with an increase in podocin by 1 ng/ml, the chances of IMT thickening increased by 3.028 times. When assessing the probability of IMT thickening using ROC analysis, a cut-off point for podocin of 0.806 ng/mL was obtained, with a sensitivity and pecificity of 71.0% and 81.0%, respectively. The area under the ROC curve was 0.778 ± 0.047 with 95% CI: 0.686 – 0.871, p < 0.001.
Conclusion. Urinary podocin in urine can be considered as an early marker of atherosclerosis in patients with type 2 diabetes, with a sensitivity of 71% and specificity of 81%.
The authors reported no conflicts of interest related to this article.
Authors’ contribution: V. Vasilkova, T. Mokhort –concept and design of this study, formation of results; I. Pchelin, N.A. Pervyshin, Y.A. Borovets – collecting and processing data, paper editing.
Ethical statement: this study was carried out in accordance with the Good Clinical Practice standards and the principles of the Declaration of Helsinki.
Informed consent: written informed consent was obtained from patients to perform research and permission to anonymously publish the results.
Registries of patients after myocardial infarction and acute cerebrovascular accident: international experience and its relevance for the Republic of Belarus
O.V. Mikulskaya, N.F. Pobivantseva, E.A. Grigorenko, N.P. Mitkovskaya
The review examines the largest foreign and Russian registries of myocardial infarction and acute cerebrovascular accidents. The main characteristics and analysis of the obtained research data are given. The relevance of developing a registry of patients with myocardial infarction and acute cerebrovascular accident on the territory of the Republic of Belarus, including the data on the clinical and epidemiological characteristics of patients, risk factors, outcomes, treatment, discharge recommendations, and medical supervision, is discussed. Introduction of such a registry in the Republic of Belarus will allow us to evaluate the real picture of patients with such kinds of pathology follow-up quality assessment over a long period of time and offer a set of measures aimed at its improvement. Introduction of registries of myocardial infarction and acute cerebrovascular accidents into medical practice will contribute to the rational planning and optimization of republican and local budget expenditures on healthcare.
Rheumatoid arthritis: a modern look at problematic nutrition issues
N.A. Martusevich, N.A. Pavlovskaya, E.I. Kislach, N.P. Mitkovskaya
The article examines the role of nutrition as an additional factor in the treatent of rheumatoid arthritis (hereinafter – RA). Foodomics data on the mechanisms of nutrition influence on the pathogenesis of RA are presented from the perspective of modulation of immuno-inflammatory processes, changes in the intestinal microbiota, and regulation of gene expression associated with inflammation. The key areas of research are summarized – from individual nutrients to complex dietary approaches. Besides, we present scientific data on the role of nutrients and beverages in reducing RA activity, as well as current recommendations from international rheumatology communities. Special attention is paid to the Mediterranean diet, which has the greatest evidence base.
Systematic review and meta-analysis of the effectiveness of coenzyme Q10 for the prevention of postoperative complications during cardiac surgery
A.V. Kotovich, A.P. Yakimchuk, I.A. Makhanovsky, O.O. Rummo, A.M. Dzyadzko, L.V. Rachok
This article presents the data from a systematic review and meta-analysis of the effectiveness of coenzyme Q10 in the framework of preabilitation. The outcomes assessed included: CK-MB level, cardiac index (CI) value 24 hours after intervention, duration of hospitalization, hsTroponin level and degree of vasopressor support 24 hours after cardiac surgery. Due to many limitations, the meta-analysis has not shown the effectiveness of coenzyme Q10, which requires investigations of proper quality for a more detailed study of this drug.
Risk factors for primary heart transplant dysfunction
A.V. Valentsiukevic, Y.A. Mishchanchuk, A.M. Troshyna, Y.A. Rahouski, U.G. Yakusheva, Z.S. Suponenko, E.A. Grigorenko, N.P. Mitkovskaya
Heart transplantation is the treatment of choice in case of identifying objective signs of severe chronic heart failure (CHF), refractory to drug therapy, inability to perform surgical reconstructive interventions due to their extremely high risk. Heart transplantations have been performed in the Republic of Belarus since 2009 and by the beginning of 2023, more than 500 such operations have been performed. The number of operations performed in the world is growing every year [1, 2].
The progress of high-tech medical care has improved survival after orthotopic heart transplantation (OHT) provided to patients with end-stage CHF over the past decade. Nowadays, the annual survival rate in the world is 90%, the five-year survival rate is equal to 75% [3].
Acute cellular and humoral rejection, infectious and surgical factors are the main causes of death among patients in the early period after OHT, but primary graft dysfunction (PGD) is the leading predictor of death. Nowadays, the hospital mortality of patients after OHT complicated by PGD stays extremely high and averages 30%. The frequency of primary graft dysfunction according to literature data ranges from 2.3% to 28.2%. Such a wide range of occurrence of this complication appears because of different approaches to diagnosis and criteria for diagnosis in various transplant centers [4].
The review article presents the criteria for the diagnosis of primary graft dysfunction, the classification of this condition and describes the main risk factors for the development of primary graft dysfunction on the part of both the donor and the recipient. Some results of our own research are presented in this article.

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  • The article meets the basic requirements for publication in the journal “Neotlozhnaya kardiologiya i kardiovaskulyarnye riski” (“Emergency Cardiology and Cardiovascular Risks”)

The journal “Neotlozhnaya kardiologiya i kardiovaskulyarnye riski” (“Emergency Cardiology and Cardiovascular Risks”) accepts the following types of articles: original articles, reviews, interesting case reports, teaching articles and other.

Authors are encouraged to use the following checklists and charts developed by international health organizations (EQUATOR, Enhancing the Quality and Transparency of Health Research) when preparing original articles and other materials: “CONSORT 2010 checklist of information to include when reporting a randomizes trial”, “The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies”, “PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)”, “The CARE Guidelines: Consensus-based Clinical Case Reporting Guideline Development”,  “SRQR (Standards for reporting qualitative research)”, “STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies”.

Before submitting the article for consideration, make sure that the file(s) contains all the necessary information, the sources of the information in the figures and tables are indicated, all citations are properly formatted.

II. Submitting of an article 

One сору of the manuscript and signed accompanying documents (letters from the institution with the head's approval, cover letter) should be sent to the editorial board by mail. It is obligatory to send an electronic version of the article, graphic materials and digital copies (scans) of accompanying documents to the e-mail address of the journal - emcardio@bsmu.by

Articles are accepted by the editorial board with a referral letter having the head's signature of the institution (see the example of the referral letter on the journal's website).

While submitting a manuscript to the editorial board of the journal the cover letter from authors must be included, where the following points should be reflected (see the example of a cover letter on the journal's website):

  • the initials and last names of the authors
  • the article title
  • information that the article has not been previously published or submitted to another journal for consideration and publication
  • the authors' commitment that if the article is accepted for publication, they will give the copyright to the publisher
  • a statement that there are no financial or other conflict of interest
  • evidence that the authors have not received any form of reward from manufacturing companies, including competitors that could influence the results of the work
  • information about the authors' participation in the creation of the article
  • information about the authors' participation in the creation of the article
  • signatures of all authors

Manuscripts that do not meet the requirements are not accepted by the editorial board and the authors are informed about this decision. Correspondence with authors is carried out only by e-mail

Materials for publication should be sent to:

The journal “Neotlozhnaya kardiologiya i kardiovaskulyarnye riski”, ul. Leningradskaya, 6, kabinet 2, Minsk, 220006, Republic of Belarus

E-mail: emcardio@bsmu.by

Website: emcardio.bsmu.by

Contact phone number: +375173285892

III. Requirements for the formatting of the article

The article must be created using the Microsoft Word text editor of any version and have the following formatting:

Width of the left/upper/bottom/right margin is 3 cm/2.5 cm/2.5 cm/1 cm.

Font– Times New Roman, 12 points.

Line spacing 1,5.

Paragraph indent 1.25 cm

Font color black 

Orientation - portrait

Hyphenation – none

Alignment – justify

Headings and subheadings are started on a new line and typed in bold with left alignment without dot at the end. 1,25 cm paragraph indentation is left before the headings. Other formatting is not allowed in the text of the article.

IV. Structure of the article

The article should have the following structure:

1. The initials and last names of the authors

2. Title of the article.

3. Full name of the institutions in which the authors work, indicating the city and country (superscript Arabic numerals indicate the correspondence of the institutions)

4. An abstract in English (1800 to 2500 characters with spaces for original articles, at least 1000 characters for reviews and case reports) should be a brief summary of a large scientific work. It can be published independently from the main text, therefore, it should be understandable without reference to the publication itself. In terms of structure, it is advisable to repeat the sections of the article (for an original articles: purpose, methods, results, conclusion). The text of the abstract should be concise and clear, free of secondary information, superfluous introductory words, and general formulations. The abstract should not contain references to literature. No abbreviations or acronyms other than the commonly used ones should be used. The results of the work are described very accurately and informative. The abstract should contain main theoretical and experimental results, actual data, the relationships and patterns that have been found. Preference is given to new results and data of long-term significance, important discoveries, conclusions that refute existing theories, as well as data that, in the opinion of the author, are of practical importance. Conclusions may be accompanied by recommendations, assessments, suggestions, hypotheses described in the article.

5. Keywords - a set of words that reflect the content of the text in terms of the object, scientific field and research methods; the recommended number of keywords - 5-10.

6. The main text of the article. Depending on the type of manuscript, the structure of the full text may vary. The volume of article including figures, tables, references and abstracts in original articles and case reports should not exceed 30 thousand characters with spaces, in reviews and teaching articles - 45 thousand characters with spaces. Word abbreviations are not allowed except for common abbreviations of chemical and mathematical quantities, measures, terms. The SI system should be used in the articles.

6.1 Original articles  

Original articles contain the results of original research. 

  • Introduction (no more than 2 pages). It should reveal the relevance of the problem that became the subject of the study including its scope (prevalence, morbidity, etc.), mediated effects (social, economic), and identify solved and unsolved aspects of the problem with an analysis of previously published data
  • Purpose of the study 
  • Methods (the section should contain information about the study design, its term, the way of assessing the results of the study, testing the hypothesis of the study with a description of statistical methods and a package for processing the results)
  • Results (a detailed summary of the content and results of the study; if necessary, this section may be divided into subsections)
  • Discussion (the results should be discussed in regard of novelty and compared with known data)
  • Сonclusion (must be presented as a comprehensive text)
  • Source of funding 1 (should specify the source of funding for the performed work)
  • Conflict of interest 2 (the presence of obvious and potential conflicts of interest - conditions and facts that can affect the results of the study or their interpretation)
  • Acknowledgement 3

6.2 Review article

The purpose of a review article is to discuss the accumulated material and present the author's new view of previously described phenomena, rethinking, and searching for new approaches to their interpretation, rather than simply listing the facts and stating the current state of the issue.

Obligatory sections of a review article:

  • Introduction 
  • Discussion (can be isolated in a separate section or run smoothly through the entire text) 
  • Conclusion - (must be presented as a comprehensive text) 
  • Source of funding 1 (should specify the source of funding for the performed work)
  • Conflict of interest 2 (the presence of obvious and potential conflicts of interest - conditions and facts that can affect the results of the study or their interpretation)
  • Acknowledgement 3

1 - you should provide information about the sources of sponsorship in the form of grants, equipment, medicines.

2 - “conflict of interest” refers to the conditions under which people have conflicting or competing interests that can influence an editorial decision. Conflicts of interest can be potential, perceived, and real. Personal, political, financial, scientific, or religious factors may affect objectivity. The author must notify the editor of a real or potential conflict of interest by including information about the conflict of interest in the appropriate section of the article. If there is no conflict of interest the author must also declare it. Sample wording: “The team of authors declares that there is no conflict of interest”. 

3 - in the Acknowledgements section, acknowledgements are given to people who participated in the work on the article, but who are not the authors. Participation in the work on the article implies: recommendations to improve the research, providing space for research, departmental control, receiving financial support, single types of analysis, providing reagents/patients/animals/other materials for the research.

7. References (number of sources should be 25 or less for an original article and 50 or less for reviews) should be compiled according to the Harvard standard (Harvard reference system). Citations in text should be indicated by a number in square brackets (e.g., [1]). References to unpublished works are not allowed. References on sources in Russian should have following structure: authors (transliteration), title of the article in transliterated version [translation of article title into English in square brackets], title of the Russian-language source (transliteration) [translation of source title into English], output data with designations in English. Transliteration of Russian-language titles is performed according to the BSI standard. Examples of formatting of the reference list are listed below. 

References to books: 

  1. Rips L.J. Lines of thought: central concepts in cognitive psychology. Oxford : Oxford Univ. Press, 2011. 441 p.
  2. de Benoist B. et al., eds. Worldwide prevalence of anaemia 1993-2005. WHO Global Database on Anaemia Geneva, World Health Organization, 2008.
  3. Sorokina T.S. Istoriya meditsinyi [History of medicine]. M.: Academia, 2008, 560 p. (in Russian).
  4. Izvekov V.I., Serikhin N.A., Abramov A.I. Proektirovanie turbogeneratorov [Design of Turbo-generators]. Moscow, MEI Publ., 2005, 440 p. (in Russian).

References to journal articles:

  1. George G.W. Vetrovec Hemodynamic Support Devices for Shock and High-Risk PCI:When and Which One. Curr Cardiol Rep. 2017, vol. 19 no.10, pp. 100. doi: 10.1007/s11886-017-0905-3. 
  2. von Drygalski A., Adamson J.W. Ironing out fatigue. Blood, 2011, vol. 118, pp. 3191-3192.
  3. Huo T.I., Lin H.C., Lee S.D. Model for end-stage liver disease and organ allocation in liver transplantation: where are we and where should we go? J Chin Med Assoc, 2006, vol. 69, no. 5, pp. 193-198.
  4. Cholongitas E., Marelli L., Shusang V., Senzolo M., Rolles K., Patch D., Burroughs A.K. A systematic review of the performance of the model for end-stage liver disease (MELD) in the setting of liver transplantation. Liver Transpl, 2006, vol. 12, no. 7, pp. 1049-1061.
  5. Ibanez B., James S., Agewall S., Antunes M.J., Bucciarelli-Ducci C., Bueno H., Caforio A.L.P., Crea F., Goudevenos J.A., Halvorsen S., Hindricks G., Kastrati A., Lenzen M.J., Prescott E., Roffi M., Valgimigli M., Varenhorst C., Vranckx P., Widimský P. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J, 2017, vol. 26. doi: 10.1093/eurheartj/ehx393.
  6. Belov Yu.V., Varaksin V.A. Strukturno-geometricheskie izmeneniya miokarda i osobennosti zentral'noy gemodinamiki pri postinfarktnom remodelirovanii levogo zheludochka [Structural and geometric changes in the myocardium and features of central hemodynamics in postinfarction remodeling of the left ventricle]. Kardiologiya. 2003, vol. 43, no. 1, pp. 19-23. (in Russian).
  7. Mit'kovskaya N.P., Toropilov D.M. Kardiorenal'nyy sindrom pri ostroy ishemicheskoy bolezni serdza [Cardiorenal syndrome in acute coronary heart disease]. Med. zhurnal, 2009, no. 1, pp. 19-23. (in Russian).
  8. Mitkovskaya N., Rummo O., Grigorenko E. Stratifikaziya riska vnezapnoy serdechnoy smerti u rezipientov transplantatov pecheni i pochek [Stratification of the risk of sudden cardiac death in recipients of liver and kidney transplants]. Kardiologiya v Belarusi, 2014, vol. 3, pp. 27-33. (in Russian).

References to articles from collection of articles: 

  1. Pavlyukovskaya E.G. Primenenie pribora spektrofotometr v stomatologicheskoy praktike [Application of the device spectrophotometer in dental practice]. Ctudenty i molodye uchyenye belorusskogo gosudarstvennogo medizinskogo universiteta - medizinskoy nauke i zdravoochraneniyu Respubliki Belarus : sb. nauch. tr. studentov i molodych uchyenych pod red. A. V. Sikorskogo, O. K. Doroninoy. Minsk : BGMU, 2016, pp. 317-320. (in Russian).

Reference to a thesis or dissertation

  1. Ponomareva M.N. Diagnostika i medikamentoznaya korrekziya narusheniy gemodinamiki pri ishemicheskoy neyropatii zritel'nogo nerva u bol'nych s serdechno-sosudistymi zabolevaniyami [Diagnosis and drug correction of hemodynamic disorders in ischemic neuropathy of the optic nerve in patients with cardiovascular diseases] : Diss. dokt. med. nauk : 14.01.07. M., 2010, 235 s. (in Russian).

Reference to patents

  1. Chichkin D.N, Ulaschik V.S., Mit'kovskaya N.P., Mucharskaya Yu.A., Kul'chizkiy V.A. Sposob lecheniya revmatoidnogo artrita [A method of treating rheumatoid arthritis]. Patent BY no 10617, 2006. (in Russian).

V. Information about the authors 

The section is provided at the end of the article and should contain the following information:

  • full name, academic title, degree, position, place of employment
  • working address, and contacts (e-mail, phone numbers, ORCID)

VI. Guidelines on Formatting Tables 

All tables should have a numbered header and clearly marked columns that are easy to read and understand. Table data should correspond to the data in the text but should not duplicate the information presented in it. References to tables in the text are obligatory.

Tables are numbered by arabic numerals in the order of the text. If there is only one table in the text then it is not numbered. The title of the table includes the table number and its name. Alignment of the title – “Left Align”. Title formatting example: Table 1. Scale of risk factors. No dot after the title is required.

Notes to the table are in the same font style and size as the main text (Times New Roman, 12 points), Alignment – “Justify”. Note is placed under the table and must contain the explanation of used abbreviations and other information which is necessary for the interpretation of the data presented in the table.

VII. Guidelines on Formatting Figures

Each figure must be accompanied by a numbered title. References to figures in the text are mandatory. 

Figures are numbered by arabic numerals in the order of the text. If there is only one figure in the text then it is not numbered. The title includes the number and the name of the figure. Alignment of the title – “Center Align”. Title formatting example: 'Figure 1. Normal electrocardiogram'. No dot after the figure title is required. A note to the figure should be in the same font style and size as the main text (Times New Roman, 12 points), Alignment – “Justify”, placed under the figure title and must contain the explanation of used abbreviations and other information which is necessary for the interpretation of the data presented in the figures.

Illustrations (graphs, diagrams, schemes, drawings) drawn with MS Office tools should be contrast and clear. Illustrations should be made in a separate file and saved as an image (in *.jpeg, *.bmp, *.gif format), and then placed in the manuscript file as a fixed figure. It is unacceptable to put any elements (arrows, captions) over the figure inserted in the manuscript file by means of MS WORD due to the great risk of their loss at the stages of editing and layout.

Photographs, screenshots, and other non-drawn illustrations should not only be inserted in the text of the manuscript but also uploaded separately as *.jpeg, *.bmp, *.gif files (*.doc and *.docx - in case additional marks are put on the image). The resolution of the image should be >300 dpi. The image files should be given a name corresponding to the number of the figure in the text.

Checklist for Preparing Material for Submission

Authors must acknowledge the following items to submit an article. The manuscript may be returned to the authors if it does not match them:

  1. The article has not been previously published nor it has been submitted for review and publication in another journal.
  2. The file of the submitted article is in Microsoft Word document format with figures and tables placed in the text after the references to them, i.e., all the information is submitted in one file.
  3. Full web addresses (URLs) for references are given where it is possible.
  4. The text is typed with the following parameters: font style – Times New Roman, font size – 12 points, line spacing 1,5, paragraph indent 12,5 mm, no word hyphenation. Margins: upper and bottom - 25 mm, left - 30 mm, right - 10 mm. All pages must be numbered; all illustrations, graphs and tables are placed in appropriate places in the text, not at the end of the document.
  5. The text complies with the stylistic and bibliographic requirements described in the 'Rules for Authors'.

The order of reviewing article manuscripts submitted to the scientific and practical peer-reviewed journal “Emergency Cardiology and Cardiovascular Risks”

Manuscripts of all scientific articles submitted to the editors are subject to mandatory review by two independent experts. Review is carried out by the scientists who are recognized experts in the field of reviewed materials and work in the field of knowledge to which the content of the manuscript belongs and who have had publications on the subject of the article under review over the last three years.

The author, supervisor of a scientific degree scholar or coauthors of the reviewed work cannot be reviewers. The review of a scientific article is issued in accordance with the Memo to the reviewer of scientific articles and materials submitted to the journal “Emergency Cardiology and Cardiovascular Risks”.

Manuscripts are not considered for publication in case they do not meet the “Rules for Authors” which are published for convenience in the journal and its electronic version.

The editor informs the author about the review result by providing a copy of the review. The review contains recommendations for publication, correction and improvement of the article or a reasonable refusal. The author of the manuscript may take into account the recommendations when preparing a new version of the article or reasonably refute them. Articles refined by the author are resubmitted for review by a reviewer who made critical comments. The incoming date is considered to be the date of the refined article submission. If the author disagrees with the reviewer's comments, he may apply for a second review engaging a third expert or withdraw the article.

Articles and article reviews are discussed at the meeting of the editorial board, which serves as a basis to accept or reject an article. The decision of the editorial board is registered in by the protocol.

The order and priority of publications are determined depending on the volume of published materials and the list of subdivisions in a particular issue.

The editorial board does not guarantee the publication of all submitted materials. The article will not be accepted for consideration if it has been published or sent to other journals, the authors have not provided their complete personal data or the article does not meet the “Rules for Authors”. The editors reserve the right to edit the article without notifying the authors.

The final decision on the expediency of publications after their reviewing is made by the editorial board.

Articles not allowed for publication:

  • manuscripts which are not related to the scientific area of the journal;
  • manuscripts which do not meet the design requirements and their authors refuse to make their technical refinement;
  • manuscripts, the authors of which did not change the article according to the constructive requirements of the reviewer;

manuscripts, representing significant plagiarism due to copying data or conclusions from another author’s research without proper citation/reference (according to the recommendations of the World Association of Medical Editors (WAME) and COPE (Committee on Publication Ethics)); resubmission of the publication under the name of another author (in the original language or in translation); verbatim copying of more than 100 words from another (including his own) publication in the absence of a properly arranged quotation; unpublished borrowings of previously published ideas or hypotheses of other authors, and/or those that have not been tested by the “Anti-plagiarism” Automatic Text Checking System for borrowing from publicly available information sources.

If plagiarism is suspected:

the editorial board informs the experts and the author(s) of the material in writing about the initiation of the editorial investigation and its expected timeframe (2 months). Based on the results of the editorial investigation, a written statement is drawn up (stored in the editorial office), copies of which are provided to the person who discovered the fact of plagiarism and the author(s) about the decision made and the undertaken actions.

In case of insignificant plagiarism the editors of the journal must notify the author about the fact of plagiarism and obtain written explanations. If a violation by the author is qualified as unintentional, confine to a reprimand and sending a message about the inappropriateness of repeated cases. A revised manuscript with references to all original sources of borrowing may be published.

Manuscripts and electronic versions of both published and unpublished materials are not returned.

Reviews are kept in the editorial office for five years.

About Us

ISSN 2616-633X

Publishing semi-annual
Articles in Russian. Summaries in English

Address:

Dzerzhinski Ave., 83, Minsk, Republic of Belarus, 220116
Tel: +375 17 277-12-01.
Fax: +375 17 277-12-02
E-mail:  emcardio@bsmu.by
Web-site:  https://emcardio.bsmu.by

Editor-in-chief: Prof. Natalya P. Mitkovskaya, MD, PhD. Educational Institution «Belarusian State Medical University», Minsk, Belarus

Executive Secretary: Ekaterina B. Petrova, PhD Educational Institution «Belarusian State Medical University», Minsk, Belarus

Executive Editorial Office Secretary: Olga V. Laskina. Educational Institution «Belarusian State Medical University», Minsk, Belarus

 

Editor-in-chief greeting

 

Publication Ethics

Editorial Board

Chairman of the editorial board: Rudenok V.V., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Gelis L.G., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Grigorenko E.A., Grand PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Gubkin S.V., Corresponding Member of the National Academy of Sciences of Belarus, Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Danilova L.I., Grand PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Dzjadz`ko A.M., Grand PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Karpov I.A., Corresponding Member of the National Academy of Sciences of Belarus, Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Kozlovkij V.i., Grand PhD in Medical sciences, Professor (Vitebsk, Belarus)

Kopitov A.V., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Medvedeva E.A., Grand PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Ostrovskij A.Yu., PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Pavlova O.S., Grand PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Petrova M.N., PhD in Philological sciences, Associate Professor (Minsk, Belarus)

Pristrom A.M., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Rudenko E.V., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Ruzanov D.Yu., PhD in Medical sciences, Associate Professor (Gomel, Belarus)

Salivonchik D.P., Grand PhD in Medical sciences, Professor (Gomel, Belarus)

Sidorovich E. K., Grand PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Sikorskiy A.V., PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Sudzhaeva O.A., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Uss A.L., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Tsapaeva N.L., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Yanushko A.V., PhD in Medical sciences, Associate Professor (Grodno, Belarus)

 

Advisory Editorial Board

(International Consultative Committee)

Chairman of the Advisory Editorial Board: Ostrovskij Ju.P., Academician of the National Academy of Sciences of Belarus,  Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Abel`skaya I.S., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Azimferey Leonhard, Grand PhD in Medical sciences, Professor (Tîrgu Mureș, Romania)

Arutjunov G.P., Corresponding Member of the Russian Academy of Sciences , Grand PhD in Medical sciences, Professor (Moscow, Russian Federation)

Bedel'baeva G.G., Grand PhD in Medical sciences, Professor (Almaty, Kazakhstan)

Beljaeva L.N., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Vismont F.I., Corresponding Member of the National Academy of Sciences o Belarus , Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Dzhunusbekova G.A., Grand PhD in Medical sciences, Professor (Almaty, Kazakhstan)

Drapkina O.M., Corresponding Member of Russian Academy of Sciences , Grand PhD in Medical sciences, Professor (Moscow, Russian Federation)

Dudarenko S.V., Grand PhD in Medical sciences, Professor (St. Petersburg, Russian Federation)

Kibira Satoshi, Grand PhD in Medical sciences, Professor (Akita, Japan)

Koziolova N.A., Grand PhD in Medical sciences, Professor (Perm, Russian Federation)

Kostjuk William, Grand PhD in Medical sciences, Professor (London, Canada)

Krasnyj S.A., Academician of the National Academy of Sciences of Belarus, Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Kul'chickij V.A., Academician of the National Academy of Sciences of Belarus,  Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Khryshchanovich V.Ya., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Linn Tommi, Grand PhD in Medical sciences, Professor (Stockholm, Sweden)

Mrochek A.G., Academician of the National Academy of Sciences of Belarus,  Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Oganov R.G., Academician of the Russian Academy of Sciences,  Grand PhD in Medical sciences, Professor (Moscow, Russian Federation)

Pershagen Joran, Grand PhD in Medical sciences, Professor (Stockholm, Sweden)

Rebrov A.P., Grand PhD in Medical sciences, Professor (Saratov, Russian Federation)

Rud Charls, Grand PhD in Medical sciences, Professor (Berkeley, USA)

Rummo O.O., Academician of the National Academy of Sciences of Belarus, Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Skugarevskij O.A., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Snezhickij V.A., Corresponding Member of the National Academy of Sciences of Belarus, Grand PhD in Medical sciences, Professor (Grodno, Belarus)

Tiffi Patrik, Grand PhD in Medical sciences, Professor (London, Canada)

Tret'jak S.I., Academician of the National Academy of Sciences of Belarus, Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Fedoruk A.M., Grand PhD in Medical sciences, Professor (Minsk, Belarus)

Hirmanov V.N., Grand PhD in Medical sciences, Professor (St. Petersburg, Russian Federation)

Zhebentyayev A.I., Grand PhD in Pharmaceutical Sciences, Professor (Vitebsk, Belarus)

Tsarenkov V.M., Grand PhD in Pharmaceutical Sciences, Professor (Minsk, Belarus)

Khishova O.M., Grand PhD in Pharmaceutical Sciences, Professor (Vitebsk, Belarus)

 

Publishing Group

Balysh E. M., PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Gerasimenok D.S., PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Kononchuk N.B., (Minsk, Belarus)

Korzhenevskaia Iu.V., (Minsk, Belarus)

Mazanik Ju.N., (Minsk, Belarus)

Martusevich N.A., PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Pinchuk A.V., Master of Pharmacological sciences (Minsk, Belarus)

Pleshko A.A., (Minsk, Belarus)

Pyko A.A., PhD in Medical sciences (Minsk, Belarus)

Rachok L.V., PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Rustamov M.N., PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Sachnova O.I., Master of Philological sciences (Minsk, Belarus)

Statkevich T.V., PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Shibeko N.A., PhD in Medical sciences, Associate Professor (Minsk, Belarus)

Zhuk L.I., Editor (Minsk, Belarus)